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大鼠降钙素检测试剂盒
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详细信息
一.产品名称：
通用名称：大鼠降钙素检测试剂盒
二.大鼠降钙素检测试剂盒产品介绍：
Rat Calcitonin IRMA Kit is a 32 amino acid peptide hormone with a 1-7 disulfide bridge synthesized primarily by thyroidal C-cells. Other tissue sources of calcitonin have been identified but they are not likely to contribute to the circulating concentration. Calcitonin circulates in various multiple molecular forms, the physiological significance of which is unknown. These consist of as many as four or five potentially immunoreactive forms which are probably polymers of calcitonin or precursor forms. Calcitonin secretion is regulated by changes in plasma calcium concentration. Acute increases in calcium concentration create an increase in peptide secretion and acute decreases produce a corresponding decrease in secretion.The primary biological action of calcitonin is the inhibition of osteoclastic bone resorption. The entire molecule with an intact 1-7 disulfide bridge is required for full biologic activity. Both nonmonomeric and monomeric forms of circulating calcitonin have biologic activity.
The metabolism of calcitonin is a complex process involving many organ systems. The kidney, however, appears to be the important organ of clearance with hormone inactivation more important than renal excretion.
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