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DY131

CAS No. : 95167-41-2

MCE 国际站：DY131

产品活性：DY131 (GSK 9089) 是一种有效的选择性的 ERRγ 和 ERRβ 激动剂，对 ERRα，ERα 和 ERβ 无效。DY131 还抑制 Smo 信号传导。

研究领域：Vitamin D Related/Nuclear Receptor  |  Stem Cell/Wnt

作用靶点：Estrogen Receptor/ERR  |  Smo

In Vitro: DY131 (0.1-30 μM; 5 days) treatment suppresses cell proliferation and reduces BrdUrd-positive cells in both LNCaP-ERRγ and LNCaP cells in a dose-dependent manner, with higher suppression in LNCaP-ERRγ clone.
DY131inhibits Shh induced accumulation of Smo::EGFP with an IC₅₀ of 0.8 μM. DY131 suppresses SAG (100 nM) induced accumulation of Smo::EGFP in the primary cilium and Gli transcription activity with an IC₅₀ of ~2 μM.
DY131 dramatically decreases phosphorylated histone H3 (pH3) marked proliferation of CGNPs induced by Shh.
A selective ERRγ agonist, DY131, inhibits the growth of the ERα-positive endometrial cancer cells but promoted that of the ERα-negative cancer cells.

In Vivo: DY131 (5 μg/kg; subcutaneous injection; every second day; for 12 days) treatment increases P450 side-chain cleavage (P450scc), StAR and HMGCoA reductase (HMGCR) while decreases hormone sensitive lipase (HSL) expressions.

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