北京Peprotech*450-01现货Recombinant Human beta-NGF*-化工仪器网-手机站

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详细信息

北京Peprotech*450-01现货Recombinant Human beta-NGF*

品编号:450-01

别名:NGF-β, beta-Nerve Growth Factor

北京Peprotech*450-01现货Recombinant Human beta-NGF*

描述:β-NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. β-NGF is a potent neurotrophic factor that signals through its receptor β-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. β-NGF also acts as a growth and differentiation factor for B lymphocytes, and enhances B-cell survival. The functional form of Recombinant Human β-NGF is a non-covalently-linked homodimer of two 13.5 kDa, polypeptide monomers that each contain 120 amino acids and three disulfide bonds, which are required for biological activity.

氨基酸序列:SSSHPIFHRG EFSVCDSVSV WVGDKTTATD IKGKEVMVLG EVNINNSVFK QYFFETKCRD PNPVDSGCRG IDSKHWNSYC TTTHTFVKAL TMDGKQAAWR FIRIDTACVC VLSRKAVRRA

来源:E.coli

纯度:Greater than 98% by SDS-PAGE gel and HPLC analyses.

生物活性:determined by its ability to stimulate chick E9 DRG neurite outgrowth. The ED₅₀ is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 10⁶units/mg.

交叉反应:Chicken, Hamster, Mouse, Rat, Human, Leech

研究领域: