Exocell—糖尿病研究相关产品

Exocell公司是一家专注于糖尿病及其并发症研究相关的产品与服务美国高科技生物制品公司，该公司提供良好的糖尿病研究产品，涵盖临床诊断、临床研究及基础实验研究领域，包括人、小鼠、 大鼠尿蛋白和糖基化蛋白，人纤连蛋白、载脂蛋白B等一系列试剂盒和抗体，其高品质的产品欧美。作为开发，营销和执行新的临床诊断化验*者，Exocell公司已经并且正在为糖尿病及其相关的肾脏和血管疾病领域的基础科研、实验动物研究以及临床诊断和治疗研究提供优质的产品和研发服务。

Exocell公司的主要产品：

一、临床诊断检测对于糖尿病及其并发症的治疗和管理至关重要，在该领域中Exocell公司提供的临床诊断相关产品包括：

Albuwell用于检测微白蛋白尿，是早期糖尿病性肾功能紊乱的明确标志物。

Creatinine用于检测尿中的creatinine.

Glycaben用于监测糖化白蛋白（中期的控糖指标）

Glycacor用于检测糖化LDL（短期控糖指标及心血管疾病风险指标）

Hemoglobin A1c参照标准（长期控糖指标）

二、临床研发类检测试剂与试剂盒测定大量人类糖尿病及其并发症的重要指标，在该领域中Exocell公司提供的相关产品包括：

Apo B Test用于检测人血浆中的apolipoprotein B

Collagen IV H用于检测 样本中的IV 型胶原

hFibronectin ELISA试剂盒用于检测人血浆中的fibronectin

Nephrin ELISA试剂盒用于检测尿液中的nephrin.

h-PODXL用于检测人组织或尿液样本中的podocalyxin

Beta-induced h3用于检测人尿液中的BIG-H3，

Troponin – H用于检测人血浆或血清中的 Troponin I，

TNF-sR2 用于检测人尿/血浆/血清中的TNF-α可溶性受体2

三、Exocell公司提供的糖尿病及其并发症的实验室研究相关产品，包括：

Albuwell M用于检测小鼠样本中的微白蛋白尿，

Nephrat II用于检测大鼠样本中的微白蛋白尿，

Albuwell C, O 及 P 用于检测狗、绵羊及非人的灵长类动物样本中的微白蛋白尿，

Collagen IV M用于检测小鼠和大鼠样本中的IV型胶原，

Creatinine Companion用于检测人和啮齿类动物的creatinine.

Glyco-Albumin R用于检测大鼠血清中的糖化白蛋白，

Nephrin ELISA to measure rodent urinary nephrin.

CRP ELISA试剂盒用于检测啮齿类动物血浆中的C-reactive蛋白.

Adiponectin ELISA试剂盒用于检测人尿和血浆中的adiponectin，

Beta-induced h3用于检测人尿中的BIG-H3，

Troponin M用于检测小鼠血浆/血清中的Troponin I，

Troponin R用于检测大鼠血浆/血清中的Troponin I，

PODXL–R用于检测啮齿类动物尿液中的podpcalyxin ，

四、糖尿病及其并发症研究相关的试剂及标准参照品，包括高特异性的单克隆抗体及高度纯化的蛋白，，在该领域中Exocell公司提供的相关产品包括：

A717:抗糖化白蛋白单克隆抗体

E85: 抗糖化血红素的单克隆抗体

ES12:抗糖化LDL的单克隆抗体

糖化血红素片段(gly Hb, HbA1c, glyHbA0, HbA1a, b)

去糖的血红素片段(degly Hb, degly HbA0)

糖化的白蛋白(NGA/SGA)

去糖化的白蛋白

部分使用Exocell公司产品的相关文献：

  1、Albuwell M：

• American Journal Physiology Renal Physiology 293:F1657-1665, 2007
  Interference with TGF-B signalling by Smad3-knockout in mice limits diabetic glomerulosclerosis without affecting albuminuria
• American Journal Physiology Renal Physiology 292:F321-329, 2007
  Soluble betaglycan reduces renal damage progression in db/db mice
• Nephron Experimental Nephrology 105:e45-e52, 2007
  Amelioration of established diabetic nephropathy by combined treatment with SMP-534 (antifibrotic agent) and losartan in db/db mice
• American Journal Physiology Renal Physiology 290:F214-F222, 2006
  Impact of genetic background on nephropathy in diabetic mice
• American Journal Physiology Heart Circ Physiology 290:H935-H940, 2006
  Angiotensin II hypertension is attenuated in interleukin-6 knockout mice
• American Journal Physiology Renal Physiology 291:F1315-F1322, 2006
  Characterization of diabetic nephropathy in a transgenic model of hypoinsulinemic diabetes
• American Journal Physiology Renal Physiology 290:F813-820, 2006
  SMP-534 ameliorates progression of glomerular fibrosis and urinary albumin in diabetic db/db mice
• American Journal Physiology Renal Physiology 290:F828-F837, 2006
  Adenosine A2a receptor activation attenuates inflammation and injury in diabetic nephropathy
• Nephron Experimental Nephrology 104:e23-e34, 2006
  Plasminogen activator inhibitor-1 deficiency has renal benefits but some adverse systemic consequences in diabetic mice
• Journal American Society Nephrology 16:27-45, 2005
  Mouse models of diabetic nephropathy
• American Society Nephrology 16:1289-1299, 2005
  Genome-wide scan in a novel IgA nephropathy model identifies a susceptibility locus on murine chromosome 10, in a region syntenic to human IGAN1 on chromosome 6q22-23
• Diabetes 54:2628-2637, 2005
  Characterization of susceptibility of inbred mouse strains to diabetic nephropathy
• American Journal Pathology 165:1243-1255, 2004
  Urinary excretion of fatty acid-binding protein reflects stress overload on the proximal tubules
• Hypertension 43:364-369, 2004
  Role for thromboxanes receptors in angiotensin-II-induced hypertension
• Journal Clinical Investigation 113:1390-1397, 2004
  Induction of B7-1 in podocytes is associated with nephritic syndrome
• Diabetes 53:2101-2109, 2004
  Diminished loss of proteoglycans and lack of albuminuria in protein kinase C-?-deficient mice
• Journal American Society Nephrology 14:1200-1211, 2003
  Focal and segmental glomerulosclerosis in mice with podocyte-specific expression of mutant ?-actinin-4
• American Journal Pathology 162:1123-1137, 2003
  RAGE drives the development of glomerulosclerosis and implicates podocyte activation in the pathogenesis of diabetic nephropathy
• Kidney International 64:1978-1985, 2003
  Gene expression profile in diabetic KK/Ta mice
• Journal of Immunology 170:5658-5666, 2003
  CC chemokine ligand 5/RANTES chemokine antagonists aggravate glomerulonephritis despite reduction of glomerular leukocyte infiltration

      2、Glycacor：

• Atherosclerosis 202:162-168, 2009
  Glycation of LDL in non-diabetic people: Small dense LDL is preferentially glycated both in vivo and in vitro
• Immunopharmacology Immunotoxicology 15:1-12, 2008
  Evaluation of serum biomarkers in nutritional disorders: Glycated apolipoprotein B, fasting serum glucose, fructosamine, stable and labile glycated hemoglobin in diabetic and non-diabetic subjects
• Nutrition Metabolism & Cardiovascular Disease 17:6-12, 2007
  Glycated apolipoprotein B and myocardial infarction
• Circulation 109:1750-1755, 2004
  Endothelial dysfunction and increased arterial intima-media thickness in children with type 1 diabetes
• Diabetes Technology & Therapeutics 6:348-356, 2004
  Increased plasma glycated low-density lipoprotein concentrations in diabetes: A marker of atherogenic risk
• Journal American Society Nephrology 10:332-341, 1999
  Non-insulin dependent diabetes mellitus and hypertriglyceridemia impair lipoprotein metabolism in chronic hemodialysis patients
• Nephrology Dialysis Transplantation 12:1336-1343, 1997
  Uptake and metabolism of lipoproteins from patients with diabetes mellitus type II by glomerular epithelial cells

3、Nephrat：

• Cell Biochemistry Biophysics 48:147-157, 2007
  Novel inhibitors of glycation and AGE formation
• American Journal Physiology Regul Integr Comp Physiology 292:R769-R777, 2007
  17-estradiol supplementation reduces tubulointerstitial fibrosis by increasing MMP activity in the diabetic kidney
• Diabetes 56:1842-1849, 2007
  Hyperglycemia is a major determinant of albumin permeability in diabetic microcirculation
• American Journal Physiology Renal Physiology 290:F828-F837, 2006
  Adenosine A2a receptor activation attenuates inflammation and injury in diabetic nephropathy
• Laboratory Investigation 86:357-368, 2006
  Expression of Smad1 is directly associated with mesangial matrix expansion in rat diabetic nephropathy
• FASEB Journal 20:E150-E159, 2006
  Cellular and molecular mechanisms of tissue protection by lipophilic calcium channel blockers
• American Journal Physiology Regul Integr Comp Physiology 290:R435-R441, 2006
  Endothelin antagonism prevents early EGFR transactivation but not increased matrix metalloproteinase activity in diabetes
• Laboratory Investigation 86:927-939, 2006
  Angiotensin II-dependent Src and Smad1 signaling pathway is crucial for the development of diabetic nephropathy
• American Journal Physiology Renal Physiology 289:F442-450, 2005
  Regulation of the renal thiazide-sensitive Na-Cl cotransporter, blood pressure, and natriuresis in obese Zucker rats treated with rosiglitazone
• Diabetologia 46:1140-1152, 2003
  LR-90 a new advanced glycation endproduct inhibitor prevents progression of diabetic nephropathy in streptozotocin-diabetic rats
• Journal American Society Nephrology 14:709-720, 2003
  Delayed treatment with lithospermate B attenuates experimental diabetic renal injury
• Journal American Society Nephrology 14:3178-3187, 2003
  Role of 12-lipoxygenase in the stimulation of p38 mitogen-activated protein kinase and collagen ?5(IV) in experimental diabetic nephropathy and ion glucose-stimulated podocytes
• American Journal Pathology 158:1733-1741, 2001
  A vitamin D analog ameliorates glomerular injury on rat glomerulonephritis
• American Journal Society Nephrology 12:993-1000, 2001
  Antibodies against vascular endothelial growth factor improve early renal dysfunction in experimental diabetes

      4、Collagen Type IV

• Diabetologia 51:198-207, 2008
  Monocyte chemoattractant protein-1 has prosclerotic effects both in a mouse model of experimental diabetes and in vitro in human mesangial cells
• Nephron Experimental Nephrology 105:e45-e52, 2007
  Amelioration of established diabetic nephropathy by combined treatment with SMP-534 (antifibrotic agent) and losartan in db/db mice
• American Journal Physiology Renal Physiol 292:F789-F795, 2007
  Inhibiting albumin glycation attenuates dysregulation of VEGFR-1 and collagen IV subchain production and the development of renal insufficiency
• American Journal Physiology Renal Physiology 290:F813-820, 2006
  SMP-534 ameliorates progression of glomerular fibrosis and urinary albumin in diabetic db/db mice
• Kidney International 68:1554-1561, 2005
  Evidence linking glycated albumin to altered glomerular nephrin and VEGF expression, proteinuria, and diabetic nephropathy
• Kidney International 64:1632-1642, 2003
  Vitamin D3 up-regulated protein-1 regulates collagen expression in mesangial cells
• Metabolism 50:1435-1440, 2001
  Increased urinary type IV collagen marks the development of glomerular [athology in diabetic db/db mice
• Diabetes Care 24:914-918, 2001
  Increased collagen IV excretion in diabetes
• Diabetes Care 24:1324-1327, 2001
  Serum type IV collagen in diabetic patients at risk for nephropathy

5、Nephrin：

• PLoS One 7(5):e36041, 2012
  Dysregulated nephrin in diabetic nephropathy of type 2 diabetes: A cross sectional study
• Am J Physiol Renal Physiol 302:F1084-F1089, 2012
  Increased urinary excretion of nephrin, podocalyxin and ?ig-h3 in women with preeclampsia

6、Podocalyxin：

• Am J Physiol Renal Physiol 302:F1084-F1089, 2012
  Increased urinary excretion of nephrin, podocalyxin and βig-h3 in women with preeclampsia

7、 βig-h3：

• Am J Physiol Renal Physiol 302:F1084-F1089, 2012
  Increased urinary excretion of nephrin, podocalyxin and βig-h3 in women with preeclampsia

详细公司及产品信息请访问：http://www.exocell。。ｃｏｍ/

世界*实验材料供应商Exocell正式授权上海起发为其中国代理，Exocell在一直是行业的*,一直为广大科研客户提供zui为优质的产品和服务,上海起发一直秉承为中国科研客户带来的产品，的服务， 签约Exocell就是为了给广大科研客户带来更加完善的产品和服务,您的满意将是我们zui大的收获

Exocell中国代理，Exocell上海代理，Exocell北京代理，Exocell广东代理，Exocell江苏代理 Exocell湖北代理, Exocell天津, Exocell黑龙江代理, Exocell内蒙古代理, Exocell吉林代理, Exocell福建代理, Exocell江苏代理, Exocell浙江代理, Exocell四川代理,

我们公司zui大优势是强大的采购，

1：基本什么都能进口，血清，抗体，耗材，还有部分限制进口的，

2： 货品全，现经营过700多个品牌，基本所有生物试剂耗材都可以进口，特别是冷偏的产品那就更有优势，

3：提供加急服务，一般1-2周到货，超过时限加急费全免

4：价格公道，绝大部分价格有优势，当然不能保证100%产品都是,因为意味着没有服务.

5：良好的信誉，大部分客户我们提供货到付款服务，客户包括清华，北大 交大 复旦，中山等100多所大学，ROCHE，阿斯利康，国药 ，fisher等500多家公司

6：我们还是santa,Advanced Biotechnologies Inc;Athens Research & Technology, bangs, BBInternational, crystalchem, dianova, FD Neurotechnologies, Inc. FormuMax Scientific, Inc; Genebridege; Glycotope Biotechnology GmbH; iduron; Innovative Research of America； Ludger ； neuroprobe; omicronbio; Polysciences; prospecbi; QA-BIO；quickzyme；RESEARCH DIETS, INC；sterlitech；sysy；TriLink BioTechnologies, Inc；worthington-biochem;zyagen;......几十家国外公司授权代理

7：我们还从事invitrogen，qiagen; abcam ;sigma;neb; roche;merck; rnd; BD; GE; pierce; BioLegend....等*批发