- 面议
起订量：
佛司可林Forskolin（Colforsin）
- 型号
该企业相似产品
凯立德生物医药技术（上海）有限公司（Chemleader Biomedical Co., Limited）是一家专门从事化学定制合成，医药中间体以及新药研发的外向型企业。
公司总部位于上海临港智能产业园区，公司专注于抗癌抗肿瘤药物科研试剂及生物活性化合物,致力打造医药研发试剂品牌，旨在为科研事业和工业领域客户提供系统的产品资源及配套技术服务。
公司6,000多种库存产品主要销往国内的诸多科研院所和大中院校以及欧美，东南亚等国家。凯立德生物的每一个产品都经过严格质量把控，每个产品在出库时都配有现批次的NMR核磁共振谱、HPLC、LC-MS以及产品分析报告单CoA等相关分析检测数据。
公司产品特色类别:肿瘤药物研究试剂、癌症研究试剂、干细胞研究试剂、生物活性小分子、多肽研究试剂、生物活性肽、药物杂质、天然产物（天然生物活性化合物、植物化学单体、药用植化单体(天然活性成分)、天然产物提取分离、天然产物合成、天然产物结构修饰、海洋活性分子定制合成。
公司主营产品线：生化试剂 & 合成砌块、抑制剂（信号通路抑制剂、抗生素和抗病毒研究抑制剂）、分子靶向药物活性化合物、高通量筛选试剂、小分子化合物库、药物筛选化合物库、天然产物对照品标准品、细胞凋亡及细胞信号转导、医药中间体、抗体、试剂盒。
定制服务：医药中间体定制合成、多肽定制合成、参考化合物定制合成、药物杂质定制合成等。
我们的优势：性价比高（化的品质 本土化的价格 ）、品种齐全、质量保证、退换货无忧。
详细信息
Forskolin(Colforsin) CAS:66575-29-9 佛司可林Forskolin(Colforsin)
Appearance:Off-white to white powder
Assay(HPLC):>98%
Product Name: Forskolin
CAS No.: 66575-29-9
Synonyms: Colforsin; ForsLean; Coleonol; HL 362; L 75-1362B; NSC 357088; NSC 375489; 7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one
Chemical Name: (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one; [3R-(3α,4aβ,5β,6β,6aα,10α,10aβ,10bα)]-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one; 5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-1H-Naphtho[2,1-b]pyran-1-one
Source: From Coleus Forskohlii
Molecular Formula: C22H34O7
Molecular Weight: 410.50
Appearance: Off-white to white powder
Assay(HPLC)≥98%
Biological Activity: Cell-permeable activator of adenylyl cyclase. Hypotensive and vasodilatory agent. Induces neuronal differentiation in stem cells and in several neuroblastoma. Used to reprogram mouse embryonic fibroblasts to induced pluripotent stem cells in combination with three other small molecules. Activates adenylate cyclase leading to an increase in the intracellular concentration of cAMP.
Cyclic AMP (cAMP) is an important signal carrier necessary for the proper biological response of cells to hormones, neurotransmitters, and other extracellular signals. Forskolin is a naturally occurring diterpene that is produced by the Indian Coleus plant (C. forskohlii). It directly activates adenylyl cyclase through its catalytic subunit and is commonly used to raise levels of cAMP in a wide variety of intact cells and tissue preparations. Forskolin binds to adenylyl cyclase in membranes from stably transfected Sf9 cells expressing type 1 adenylyl cyclase with an IC50 value of 41 nM and demonstrates an EC50 value of 0.5 μM in an activation assay assessing formation of cAMP from ATP. Forskolin also interacts with glucose transporters and certain ion channels and has been used for examining adenylyl cyclase expression, regulation, and G protein signaling.
The major cell-permeable diterpene isolated from the Indian plant Coleus forskohlii. At low doses, it acts as a positive inotropic agent. At higher doses, it serves as a hypotensive and vasodilatory agent due to its actions as a smooth muscle relaxant. No major side effects are observed at effective doses. Forskolins pharmacological activities are due to its activation of adenylate cyclase (EC50 = 4 µM), resulting in increased cAMP levels. The exact mechanism of forskolins positive inotropic effect is unknown but may be related to a cAMP-dependent increase in Na+ permeability that results in indirect augmentation of Ca2+ release. Inhibits MAP kinase in rat renal mesangial cells (IC50 = 25 µM). Also acts as a Hh pathway antagonist. Shown to inhibit apoptosis in cerebellar granule cells and to induce apoptosis in resting human B lymphocytes.
An adenylate cyclase activator and MAP kinase inhibitor. Forskolin is a diterpenoid isolated from Coleus forskohlii, interacts directly with the catalytic subunit of A cyclase (adenylate cyclase), activating the enzyme and raising intracellular levels of cAMP. Forskolin is cell permeable and active in vivo producing positive inotropic, plaet anti-aggregatory and anti-hypertensive effects. Has also been shown to exhibit smooth muscle relaxant activity, decrease in intraocular pressure and the promotion of hormonal release from the pituitary glands. Inhibits MAP kinase, induces phosphorylation of CREB, connexin 43, Bad, ATF-1 and PKB. Forskolin is an inhibitor of AChR.
Forskolin is a cell permeable diterpenoid isolated from Coleus forskohlii. Cell-permeable diterpenoid that possesses anti-hypertensive, positive inotropic, and adenylyl cyclase activating properties. Many of its biological effects are due to its activation of adenylyl cyclase and the resulting increase in intracellular cAMP concentration.Forskolin effects calcium currents and inhibits MAP kinase.
