全身体积描记系统(猴)产品描述：

（whole-bodyplethysmograph，WBP）可以对清醒自由活动的大动物进行肺功能及气道反应相关的测试，避免了创伤性气管切开术及麻醉的影响，使实验过程简便快捷，并适合长期跟踪研究。

塔望科技开发的大动物全身体积描记系统，可用于猴的测量。测量时可直接将猴椅放入描记器内，通过软件可实时测量猴子的呼吸参数。

产品特点

1、适用动物：猴；

2、不需要做手术，操作简单；

3、可在动物在自然状态下呼吸的研究以及长期跟踪实验，适合进行药物初筛；

4、具有药物气溶胶雾化模块；

5、具有自动标定功能；

6、可选配测量心电、血压、体温、心率等指标，可与植入式遥测设备联合使用；

7、具有分析软件，数据可保存至excel或txt格式；

全身体积描记系统(猴)（检测参数）：

1、Ti：吸气时间（s）；

2、Te：呼气时间（s）；

3、PIF：最大吸气流速（ml/s）；

4、PEF：最大呼气流速（ml/s）；

5、Volbal：吸气时间/呼气时间；

6、F：呼吸频率（次/min）；

7、Vt：潮气量（ml）；

8、Mv：分钟通气量（ml）；

9、AV：累积体积（ml）；

10、EF50：呼出50%气量时对应的呼气流速（ml/s）；

11、EIP：吸气峰值压力（仅在侵入式法测量时有效）；

12、EEP：呼气峰值压力（仅在侵入式法测量时有效）；

13、TR：松弛时间；

14、PenH：增强呼气间歇（enhanced pause）；

15、Rpef：相对时间；

适用领域：

1、各种呼吸疾病研究，如：哮喘、肺纤维化、肺损伤、ARDS、肺癌等。

2、安全药理：药物对呼吸系统的影响。

3、睡眠呼吸：监测动物低通气、阻塞性呼吸暂停等。

4、环境毒理：环境污染物对动物呼吸的影响。

5、吸入式毒理：染毒物质对呼吸系统的毒性影响。

6、高原医学：高原环境对呼吸系统的影响。

7、其它需要对呼吸参数评价的场合。

我公司可以根据客户的特殊应用、特殊需求提供功能定制服务，也可以提供相关的实验服务，详情请询问客服。

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相关文献：

[1]Sun Lingna, Fan Mingrui, Huang Dong, Li Bingqin, Xu Ruoting, Gao Feng, Chen Yanzuo. "Clodronate-loaded liposomal and fibroblast-derived exosomal hybrid system for enhanced drug delivery to pulmonary fibrosis" [J]. Biomaterials,  2021.

[2]李宁, 李红鹏, 张本炎, 张柳, 沈继敏, 李庆云. "高脂膳食对小鼠呼吸功能和膈肌纤维的影响及其线粒体机制" [J]. 中华医学杂志,  2021,101(36):2893-2899.

[3]Xiong Jiaying,  Zhuang Tao, Ma Yurong,  Xu Junyi, Ye Jiaqi, Ma Ru, Zhang Shuang, Liu Xin, Liu Bi-Feng, Hao Chao,  Zhang Guisen,  Chen Yin. "Optimization of bifunctional piperidinamide derivatives as σ1R Antagonists/MOR agonists for treating neuropathic pain" [J]. European Journal of Medicinal Chemistry, 2021, 226:

[4]Yumei Zhou, Haihong Zhao, Tieshan Wang, Xiaoshan Zhao, Ji Wang and Qi Wang, " Anti-Inflammatory and Anti-asthmatic Effects of TMDCT Decoction in Eosinophilic Asthma Through Treg/ Th17 Balance" [J].Frontiers, 2022.819728:

[5]Yumei Zhou, Tieshan Wang, Xiaoshan Zhao, Ji Wang and Qi Wang, "Plasma Metabolites and Gut Microbiota Are Associated With T cell Imbalance in BALB/c Model of Eosinophilic Asthma" [J].Frontiers, 2022. 819747:

[6]Zheng R, Yang W, WenYet al. "Dnah9 mutant mice and organoid models recapitulate the clinical features of patients with PCD and provide an excellent platform for drug screening"  [J].Cell Death Dis 13, 559 (2022).

[7]Wang W, Mu M, Zou Y, Li B, Cao H, Hu D, Tao X. "Inflammation and fibrosis in the coal dust-exposed lung described by confocal Raman spectroscopy"  [J].PeerJ 10:e13632.

[8]Dongyi Zhu, Qian Zhang, Qinchuan Li, Guangxue Wang, Zhongliang Guo. "Inhibition of AHNAK nucleoprotein 2 alleviates pulmonary fibrosis by downregulating the TGF-β1/Smad3 signaling pathway" [J].The Journal of Gene Medicine, Volume24/Issue9/September 2022/e3442.

[9]Jiawen Zhou, Haiyun Chen, Qiuyi Wang, Sihan Chen, Rong Wang, Ziyang Wang, Cuicui Yang, Ao Chen, Jingyu Zhao, Zihao Zhou, Zhiyuan Mao, Guoping Zuo, Dengshun Miao, Jianliang Jin. "Sirt1 overexpression improves senescence-associated pulmonary fibrosis induced by vitamin D deficiency through downregulating IL-11 transcription" [J].Aging CellVolume 21, Issue 8 e13680.

[10]Yapeng, LuPanpanChang, WangwangDing, JiangpeiBian, DanWang, XuetingWang, QianqianLuo, XiaomeiWu, LiZhu. "Pharmacological inhibition of mitochondrial division attenuates simulated high-altitude exposure-induced cerebral edema in mice: Involvement of inhibition of the NF-κB signaling pathway in glial cells" [J].European Journal of Pharmacology, Volume 929, 15 August 2022, 175137.

[11]Mengjun Zhanga, Huiyang Jiang, Lan Wu,  Haoyu Lu, Hriday Bera, Xing Zhao, Xiong Guo, Xulu Liu, Dongmei Cun, Mingshi Yang. "Airway epithelial cell-specific delivery of lipid nanoparticles loading siRNA for asthma treatment" [J]. Journal of Controlled Release, Volume 352.

[12]Xue Lu, Zhu-Xia Tan, Wen-Jing Wang, Ping Zhan, Yan Wang, Lin Fu, Lan Gao, Hui. Zhao, Hua Wang, De-Xiang Xu. "Juvenile arsenic exposure aggravates goblet cell hyperplasia and airway mucus secretion in ovalbumin-sensitized mice" [J]. Environmental Pollution, Volume 315, 120462.

[13]Gu W, Lei J., Zhu, H. et al. Effect of the BMPR-II-SMAD3/MRTF pathway on proliferation and migration of ASMCs and the mechanism in asthma [J].Mol Biol Rep 49, 9283–9296 (2022).

[14]Hu M, Yang J, Xu Y, Liu J. MDH1 and MDH2 Promote Cell Viability of Primary AT2 Cells by Increasing Glucose Uptake. Computational and Mathematical Methods in Medicine  [J]. Hindawi Computational and Mathematical Methods in Medicine/Volume 2022, Article ID 2023500, 15 pages.

[15]Zhou J, Chen H, Wang Q, Chen S, Wang, R, Wang Z, Yang C, Chen A, Zhao J, Zhou Z, Mao Z, Zuo G, Miao D, & Jin J. "Sirt1 overexpression improves senescence-associated pulmonary fibrosis induced by vitamin D deficiency through downregulating IL-11 transcription" [J]. Aging Cell, 21, e13680.

[16]WenJing Wang , Xue Lu , Zhao Li , Kun Peng , Ping Zhan , Lin Fu , Yan Wang , Hui Zhao , Hua Wang , De-Xiang Xu , Zhu-Xia Tan.”Early-life cadmium exposure elevates susceptibility to allergic asthma in ovalbumin-sensitized and challenged mice”[J] Ecotoxicology and Environmental Safety 255 (2023) 114799

[17]Zhou Y, Hu L, Zhang H, Zhang H, Liu J, Zhao X, Wang J, Wang Q."Guominkang formula alleviate inflammation in eosinophilic asthma by regulating immune balance of Th1/2 and Treg/Th17 cells."[J].Frontiers in Pharmacology, 14 Oct 2022, 13:978421

[18]Bao XC, Wang N, Xu J, Ma J and Fang Y-Q (2023) “Effects of different simulated submarine escape depths by free ascent in animal models. “[J]Front. Physiol. 14:1107782.

[19]Haiyun Chen, Qiuyi Wang, Jie Li, Yuan Li, Ao Chen, Jiawen Zhou, Jingyu Zhao,

Zhiyuan Mao, Zihao Zhou, Yue Wang, Rong Wan, Qing Li, Yongjie Zhang, Runqiu Jiang,Dengshun Miao, Jianliang Jin, “IFN Transcribed by IRF1 in CD4 + Effector Memory T Cells Promotes Senescence-Associated Pulmonary Fibrosis” [J]. Aging and Disease, DOI: 10.14336/AD.2023.0320

[20]Yimeng Shu, Ming Ma, Xiaoxia Pan, Muhammad Shafiq, Huizhu Yu, Hangrong Chen,Cobalt protoporphyrin-induced nano-self-assembly for CT imaging, magnetic-guidance, and antioxidative protection of stem cells in pulmonary fibrosis treatment,[J]Bioactive Materials,Volume 21,2023,Pages 129-141,ISSN 2452-199X