TargetMol®半胱氨酸共价库-化工仪器网-手机站

随着国内新药研发事业的蓬勃发展，陶术的客⼾群体不断扩⼤，相应的需求也在不断变化。药物筛选过程中往往涉及⼤量化合物分⼦的实验操作，⾃动化的仪器设备减少了操作重复性，⼤幅提⾼了实验效率。我们在为客⼾提供抑制剂、化合物库、技术服务的同时，也开辟了包括移液⼯作站、⾃动封板仪在内的各类⾼效实验⼯具产品线，全⾯助⼒⾏业升级，打造智能实验室。

TargetMol®是⼀家全球性的⾼科技企业，总部位于⻢萨诸塞州波⼠顿，专业从事化学和⽣物产品的供应及相关服务，以满⾜全球客⼾的研究需求。陶术生物是TargetMol®品牌中国区合作伙伴。⽬前TargetMol®已发展成为全球具特⾊的化合物库和活性⼩分⼦供应商之⼀，客⼾遍及40 多个国家，可提供超过150种不同类型的化合物库和⼀系列⾼质量的研究化学品，包括抑制剂、活化剂、天然化合物、肽、抑制抗体和新型⽣命科学试剂盒，移液工作站、自动封板仪等供实验室和科学使⽤。此外，我们也为希望进⾏计算机辅助药物发现的客⼾提供虚拟筛选服务。

详细信息

TargetMol®半胱氨酸共价库
We designed a cysteine-specific covalent library. The electrophilic "warhead" of the fragments is acrylamide or chloroacetamide (25% and 75% of the library, respectively). These functional groups were chosen to construct the compound library because they are in the "best position" for reactivity and show selectivity in chemical proteomics screening. The cysteine covalent library contains 72 compounds.

TargetMol®半胱氨酸共价库Product Description

The theoretical basis of FBDD is to select favorable fragment combinations or extensions to obtain new drug molecules, with a higher probability of obtaining highly active drug candidates. Compared with the screening of millions of macromolecules, thousands of fragment molecules can be combined to form millions of drug structures, which are easier to collect and manage. In addition, fragments have smaller molecular weights, relatively higher solubility, and easier structural optimization. The potential of over-the-counter medicine is higher. In recent years, covalent chemical probes have become an important tool for drug discovery. A large number of successful applications in the evaluation of protein druggability, especially the successful application of Cys residues, bring hope for the discovery and synthesis of new covalently modified compounds. To this end, we designed a cysteine-specific covalent library. The electrophilic "warhead" of the fragments is acrylamide or chloroacetamide (25% and 75% of the library, respectively). These functional groups were chosen to construct the library because they are in the "best position" for reactivity and show selectivity in chemical proteomics screening.

化合物库定制
我们的化合物库可以灵活定制！了解更多

品牌介绍：
TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化领域科学家的研究提供专业的产品和服务。TargetMol品牌的客户群分布于40多个国家和地区，已发展成为丰富大的化合物库和小分子化合物研究供应商之一。

☆ TargetMol®品牌专业提供各领域信号通路小分子抑制剂、拮抗剂、天然产物、药物筛选化合物。
☆ 产品适应在癌症、免疫学、心血管系统、呼吸、神经科学等多项科学领域的研发使用，超过1180万种小分子化合物。
☆ 提供20000多个小分子抑制剂、天然产物和200多个化合物库。
☆ 配备完善的化学合成和生物实验室，可分别提供高品质小分子抑制剂和药物筛选技术服务。
☆ 每批产品都有严格的NMR和HPLC技术检测，以保证产品高纯度高质量。