TargetMol®高溶解性卤化片段库

The High Solubility FragLite Fragment Library contains small halogenated fragments and halogenated peptide mimic fragments. FragLites are small halogenated fragments that can be used to effectively map drug interactions in new proteins. PepLites is a small halogenated peptide mimic, designed in parallel with FragLites to cover a wider range of drug interactions in new proteins. The highly soluble halogenated fragment library contains 796 halogenated fragment compounds.
 

Product Description

The theoretical basis of FBDD is to select favorable fragment combinations or extensions to obtain new drug molecules, with a higher probability of obtaining highly active drug candidates. Compared with the screening of millions of macromolecules, thousands of fragment molecules can be combined to form millions of drug structures, which are easier to collect and manage. In addition, fragments have smaller molecular weights, relatively higher solubility, and easier structural optimization. The potential of over-the-counter medicine is higher. The FragLites identify productive drug-like interactions, which are identified sensitively and unambiguously by X-ray crystallography, exploiting the anomalous scattering of the halogen substituent. This mapping of protein interaction surfaces provides an assessment of druggability and can identify efficient start points for the de novo design of hit molecules incorporating the interacting motifs.

Combine fragments from FragLites to generate fragment lead compounds:

化合物库定制

我们的化合物库可以灵活定制！ 了解更多
 

品牌介绍：
TargetMol Chemicals Inc. 总部位于马萨诸塞州波士顿，致力于为全球生化域科学家的研究提供业的产品和服务。TargetMol品牌的客户群分布于40多个国家和地区，已发展成为全球大的化合物库和小分子化合物研究供应商之一。

☆ TargetMol®品牌业提供各域信号通路小分子抑制剂、拮抗剂、天然产物、药物筛选化合物。
☆ 产品适应在癌症、免疫学、心血管系统、呼吸、神经科学等多项科学域的研发使用，超过1180万种小分子化合物。
☆ 提供20000多个小分子抑制剂、天然产物和200多个化合物库。
☆ 配备完善的化学合成和生物实验室，可分别提供高品质小分子抑制剂和药物筛选技术服务。
☆ 每批产品都有严格的NMR和HPLC技术检测，以保证产品高纯度高质量。