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高尔基体自身蛋白GM130抗体 Anti-GM130
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生物技术领域的技术开发，转让，咨询，服务，设备，化工原料及产品
上海田源生物技术有限公司 Shanghai Tiyo Biotechnology Co,ltd.
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详细信息
高尔基体自身蛋白GM130抗体Anti-GM130的产品说明（为您现货供应，详询）：
--产品介绍：The docking of transport vesicles to their target membrane is mediated by p115. GM130, a cis-Golgi matrix protein, interacts specifically with p115 and provides a membrane docking site. Both GM130 and p115 are involved in vesicle tethering to Golgi membranes. The amino-terminus of GM130 binds to p115, whereas the carboxy-terminus binds to Golgi membranes. Both Giantin and GM130 compete for binding to p115. Thus, p115-Giantin and p115-GM130 interactions might mediate independent membrane tethering events. Transport from the ER to the cis/medial Golgi compartments requires the action of p115, GM130 and Giantin via a sequential rather than a coordinate mechanism. Mitotic phosphorylation of GM130 at Serine 25 is mediated by Cdc2, prevents binding to p115 and is directly involved in mitotic Golgi fragmentation. GM130 is phosphorylated in prophase as the Golgi complex starts to break down, and remains phosphorylated in metaphase and anaphase. In ophase, GM130 is dephosphorylated by PP2A as the Golgi fragments start to reassemble.Subcellular Location : Golgi apparatus, Golgi stack membrane; Peripheral membrane protein.Similarity : Belongs to the GOLGA2 family.Subunit : Part of a larger oligomeric complex. Interacts with p115. Interacts with RAB1B that has been activated by GTP-binding. Interacts with GORASP1/GRASP65 and ZFPL1.
--该抗体来源于：（Rabbit）
--高尔基体自身蛋白GM130抗体的参数介绍：
1、浓度：1mg/1ml
2、交叉反应：hu, mo, rat, cow, pig
3、产品类型：一抗
4、研究领域：细胞生物免疫学细胞类型标志物
5、蛋白分子量：predicted molecular weight: 110kDa
6、性状：Lyophilized or Liquid
7、免疫原：KLH conjugated synthetic peptide derived from human GM130
8、亚型：polyclonal
9、纯化方法：affinity purified by Protein A
10、储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
11、产品应用：WB=1:100-500ELISA=1:500-1000IP=1:20-100IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
12、保存条件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
（1mg/1ml高尔基体自身蛋白GM130抗体Anti-GM130，的相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗）
--产品介绍：The docking of transport vesicles to their target membrane is mediated by p115. GM130, a cis-Golgi matrix protein, interacts specifically with p115 and provides a membrane docking site. Both GM130 and p115 are involved in vesicle tethering to Golgi membranes. The amino-terminus of GM130 binds to p115, whereas the carboxy-terminus binds to Golgi membranes. Both Giantin and GM130 compete for binding to p115. Thus, p115-Giantin and p115-GM130 interactions might mediate independent membrane tethering events. Transport from the ER to the cis/medial Golgi compartments requires the action of p115, GM130 and Giantin via a sequential rather than a coordinate mechanism. Mitotic phosphorylation of GM130 at Serine 25 is mediated by Cdc2, prevents binding to p115 and is directly involved in mitotic Golgi fragmentation. GM130 is phosphorylated in prophase as the Golgi complex starts to break down, and remains phosphorylated in metaphase and anaphase. In ophase, GM130 is dephosphorylated by PP2A as the Golgi fragments start to reassemble.Subcellular Location : Golgi apparatus, Golgi stack membrane; Peripheral membrane protein.Similarity : Belongs to the GOLGA2 family.Subunit : Part of a larger oligomeric complex. Interacts with p115. Interacts with RAB1B that has been activated by GTP-binding. Interacts with GORASP1/GRASP65 and ZFPL1.
--该抗体来源于：（Rabbit）
--高尔基体自身蛋白GM130抗体的参数介绍：
1、浓度：1mg/1ml
2、交叉反应：hu, mo, rat, cow, pig
3、产品类型：一抗
4、研究领域：细胞生物免疫学细胞类型标志物
5、蛋白分子量：predicted molecular weight: 110kDa
6、性状：Lyophilized or Liquid
7、免疫原：KLH conjugated synthetic peptide derived from human GM130
8、亚型：polyclonal
9、纯化方法：affinity purified by Protein A
10、储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
11、产品应用：WB=1:100-500ELISA=1:500-1000IP=1:20-100IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
12、保存条件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
（1mg/1ml高尔基体自身蛋白GM130抗体Anti-GM130，的相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗）
