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核仁蛋白C23抗体 Anti-Nucleolin/C23
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详细信息
核仁蛋白C23抗体Anti-Nucleolin/C23的产品说明（为您现货供应，详询）：
--产品介绍：Nucleolin is the major nucleolar protein of growing eukaryotic cells. C23 （nucleolin, NCL） is a eukaryotic nucleolar phosphoprotein that influences synthesis and maturation of ribosomes. C23 localizes to dense fibrillar regions of the nucleolus. It contains four RNA binding domains that interact with pre-rRNA during synthesis. C23 can influence RNA processing, ribosomal gene transcription and nucleolar targeting of ribosomal components. It is known to associate with a variety of proteins, including the nucleolar protein B23. Phosphorylation by Cdc2 and casein kinase II causes translocation of C23 from the nucleolus to the cytoplasm. Mitotic phosphorylated forms of Bcl-2 are present in nuclear structures in prophase Hela cells together with C23 and Ki-67. Retinoic acid-induced apoptosis leads to C23 down-regulation and Bcl-2 mRNA instability. C23 binds the human omerase reverse transcriptase subunit （TERT） through interactions with its RNA binding domain 4 and carboxyl-terminal RGG domain, and this interaction is critical for the nucleolar localization of human TERT.Subcellular Location : Nucleus
--该抗体来源于：（Rabbit）
--核仁蛋白C23抗体的参数介绍：
1、浓度：1mg/1ml
2、交叉反应：hu, mo, rat
3、产品类型：一抗
4、研究领域：细胞生物染色质和核信号表观遗传学
5、蛋白分子量：predicted molecular weight: 76kDa
6、性状：Lyophilized or Liquid
7、免疫原：KLH conjugated synthetic peptide derived from hu Nucleolin/C23
8、亚型：polyclonal
9、纯化方法：affinity purified by Protein A
10、储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
11、产品应用：WB=1:100-500ELISA=1:500-1000IP=1:20-100IHC-F=1:100-500IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
12、保存条件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
（1mg/1ml核仁蛋白C23抗体Anti-Nucleolin/C23，的相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗）
请点击此处，上海田源现货直销，订购！详细目录查询https://www.chem17.com/st233816/erlist_675408.html
--产品介绍：Nucleolin is the major nucleolar protein of growing eukaryotic cells. C23 （nucleolin, NCL） is a eukaryotic nucleolar phosphoprotein that influences synthesis and maturation of ribosomes. C23 localizes to dense fibrillar regions of the nucleolus. It contains four RNA binding domains that interact with pre-rRNA during synthesis. C23 can influence RNA processing, ribosomal gene transcription and nucleolar targeting of ribosomal components. It is known to associate with a variety of proteins, including the nucleolar protein B23. Phosphorylation by Cdc2 and casein kinase II causes translocation of C23 from the nucleolus to the cytoplasm. Mitotic phosphorylated forms of Bcl-2 are present in nuclear structures in prophase Hela cells together with C23 and Ki-67. Retinoic acid-induced apoptosis leads to C23 down-regulation and Bcl-2 mRNA instability. C23 binds the human omerase reverse transcriptase subunit （TERT） through interactions with its RNA binding domain 4 and carboxyl-terminal RGG domain, and this interaction is critical for the nucleolar localization of human TERT.Subcellular Location : Nucleus
--该抗体来源于：（Rabbit）
--核仁蛋白C23抗体的参数介绍：
1、浓度：1mg/1ml
2、交叉反应：hu, mo, rat
3、产品类型：一抗
4、研究领域：细胞生物染色质和核信号表观遗传学
5、蛋白分子量：predicted molecular weight: 76kDa
6、性状：Lyophilized or Liquid
7、免疫原：KLH conjugated synthetic peptide derived from hu Nucleolin/C23
8、亚型：polyclonal
9、纯化方法：affinity purified by Protein A
10、储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
11、产品应用：WB=1:100-500ELISA=1:500-1000IP=1:20-100IHC-F=1:100-500IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
12、保存条件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
（1mg/1ml核仁蛋白C23抗体Anti-Nucleolin/C23，的相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗）
请点击此处，上海田源现货直销，订购！详细目录查询https://www.chem17.com/st233816/erlist_675408.html
