1.Deep learning-based automated pipeline for blood vessel detection and distribution analysis in multiplexed prostate cancer images. Karageorgos GM, Cho S, McDonough E, Chadwick C, et al. Front. Bioinform. (2024)

2.A single cell atlas of frozen shoulder capsule identifies features associated with inflammatory fibrosis resolution. Ng,M.T.H.,Borst, R.Gacaferi, H. et al. Nat Commun (2024).

3.3D reconstruction of skin and spatial mapping of immune cell density, vascular distance and effects of sun exposure and aging. Ghose, S., Ju, Y., McDonough, E. et al. Commun Biol (2023).

白激光：随着生物研究对同时观察多重事件的需求日增，传统共聚焦显微技术在多色标记实验中面临光谱重叠引起的限制。STELLARIS 白激光的高度可调性能够精确匹配样本染料的光谱特性，优化了多色实验的清晰度与精确度，可以通过单次成像实现11色，并且没有串色的干扰，突破传统固定激光器在多色成像上的限制。

荧光寿命：传统荧光成像受限于荧光类型和光谱范围，而STELLARIS共聚焦平台可升级荧光寿命技术，通过记录分子在激发态停留的平均时间，来区分微环境中不同的组成部分。荧光寿命与荧光物质的自身结构和所处的微环境（如极性、粘度等）有关，而与激发光强度、荧光团浓度等因素无关，是一种非常好的技术来探究肿瘤微环境中的pH值、离子浓度等。通过结合荧光寿命的维度，帮助科研工作者产生更多的新洞见。

1.LRRK2 is required for CD38-mediated NAADP-Ca(2+) signaling and the downstream activation of TFEB (transcription factor EB) inimmune cells. Nabar NR, Heijjer CN, Shi CS, Hwang IY, Ganesan S, Karlsson MCI, Kehrl JH. Autophagy. (2022)

2.Phosphatidic acid suppresses autophagy through competitive inhibition by binding GAPC (glyceraldehyde-3-phosphate dehydrogenase)and PGK (phosphoglycerate kinase) proteins. Guan B, Jiang YT, Lin DL, Lin WH, Xue HW. Autophagy. (2022)

3.Molecular sensors reveal the mechano-chemical response of Phytophthora infestans walls and membranes to mechanical andchemical stress. Michels L, Bronkhorst J, Kasteel M, de Jong D, Albada B, Ketelaar T, Govers F, Sprakel J. Cell Surf. (2022)

4.PICASSO allows ultra-multiplexed uorescence imaging of spatially overlapping proteins without reference spectra measurements.Seo, J., et al., Nat. Comm., (2022).

5.IBEX: A versatile multiplex optical imaging approach for deep phenotyping and spatial analysis of cells in complex tissues. Radtke, A.J. et al., PNAS. (2020).

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