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HY-12071A LDN193189盐酸盐（的同义词LDN193189盐酸盐; LDN-193189盐酸盐）机制：ALK

LDN193189盐酸盐技术参数：价格和可用性LDN193189盐酸盐

LDN193189盐酸盐M.Wt：442.94

LDN193189盐酸盐分子式：C25H23ClN6

LDN193189的盐酸纯度：>98％

LDN193189盐酸贮存：贮存在-20℃2年

LDN193189盐酸盐CAS号：1062368-62-0

LDN193189盐酸盐溶解性：DMSO

生物活性LDN193189盐酸：

LDN193189是一种高度有效的小分子BMP抑制剂;抑制BMP I型受体ALK2（IC50：nM的5个），ALK3（IC50：30纳米）和ALK6（TGFβ1/BMP信令）和随后的SMAD蛋白的磷酸化; LDN193189是有用的工具中的干细胞生物学。 LDN193189显示在体内的临床应用价值，抑制FOP和异位骨化和潜在的代理人在治疗非小细胞肺癌肺肿瘤具有重要意义。

HY-12071A  LDN193189 hydrochloride (Synonyms  LDN 193189 hydrochloride; LDN-193189 hydrochloride)   Mechanisms:ALK 
LDN193189 hydrochloride M.Wt: 442.94
LDN193189 hydrochloride Formula: C25H23ClN6
LDN193189 hydrochloride Purity: >98%
LDN193189 hydrochloride Storage: at -20℃ 2 years
LDN193189 hydrochloride CAS No.: 1062368-62-0
LDN193189 hydrochloride Solubility: DMSO     
5mg
10mg
50mg
Biological Activity of LDN193189 hydrochloride: 
LDN193189 is a highly potent small molecule BMP inhibitor; inhibiting BMP type I receptors ALK2 (IC50: 5 nM), ALK3 (IC50: 30 nM) and ALK6 (TGFβ1/BMP signaling) and subsequent SMAD phosphorylation; LDN193189 is useful tool in stem cell biology. LDN193189 shows significant in vivo clinical utility, inhibiting FOP and ectopic ossification and a potential agent in the treatment of NSCLC lung tumors.