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【公司名称】 广州健仑生物科技有限公司
【】    杨永汉 
【】 
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但是，Raz及其同事们发现，TPRV1也在肠道上皮细胞表达，在那里它被表皮生长因子受体(EGFR)激活。EGFR是肠道中细胞增殖的一个重要驱动力，大约每四到六天，肠道上皮层就被替换。
本文*作者Petrus de Jong博士称：“保持肠道内正常细胞更新，需要一个基本水平的EGFR活性。然而，如果EGFR信号是无限制的，散发性肿瘤的发展风险就会增加。”
科学家们发现，一旦TRPV1被EGFR激活，可引发一种对EGFR的直接负反馈，从而抑制后者降低不必要的生长和肠道肿瘤发展风险。他们发现，缺乏TRPV1的转基因小鼠，肠道肿瘤的生长率高于正常。
de Jong称：“这些结果表明，上皮TRPV1通常作为肠道内的一个肿瘤抑制基因。”此外，zui近对人结肠直肠癌样本的分子研究，发现了TRPV1基因中的多个突变，然而Raz指出，目前还没有直接的证据表明，TRPV1缺陷是人类结直肠癌的危险因素。他说：“在今后的临床研究中，应该解决TRPV1功能和人结直肠癌之间的直接关联。”
但是，如果这是事实的话，当前的研究指出，一种潜在的治疗方法可能是辣椒素，它作为哺乳动物的一种刺激物，与组织接触产生一种灼热感。辣椒素已被广泛用作外用药膏的镇痛药，其性质是作为一种压倒神经的刺激物，使神经不能长时间的疼痛。它也是胡椒喷雾剂的活性成分。
研究人员给遗传上更倾向于患多种胃肠道肿瘤的小鼠喂食辣椒素。这种治疗方法导致肿瘤负担减少，使小鼠的寿命延长了超过30%。当联合塞来昔布(celecoxib，一种COX-2非甾体类抗炎药物，已被批准用于治疗一些形式的关节炎和疼痛)使用时，治疗更加有效。
在一个共同合作中，研究人员在纽约州立大学水牛城分校的莫成?帕特尔博士以及劳森健康研究院和加拿大西安大略大学的大卫?希尔博士的带领之下，评估粒线体中的综合酵素--丙酮酸脱氢酶复合体在小鼠新生期间如何调控胰岛的β细胞的发育和成熟。

However, Raz and colleagues found that TPRV1 is also expressed in intestinal epithelial cells, where it is activated by the epidermal growth factor receptor (EGFR). EGFR is an important driver of cell proliferation in the gut, and the gut epithelium is replaced every about four to six days.
"The maintenance of normal cell renewal in the intestine requires a basic level of EGFR activity, but if the EGFR signal is unrestricted, the risk of developing sporadic tumors is increased," said lead author Petrus de Jong.
Scientists have found that once TRPV1 is activated by EGFR, it can trigger a direct negative feedback on EGFR, thereby inhibiting the latter from reducing the risk of unnecessary growth and intestinal tumor development. They found that, in the absence of TRPV1 transgenic mice, the growth rate of intestinal tumors was higher than normal.
"These results show that epithelial TRPV1 is often used as a tumor suppressor in the gut." In addition, a recent molecular study of human colorectal cancer samples revealed multiple mutations in the TRPV1 gene, de Jong said. However, Raz noted that at present There is no direct evidence that TRPV1 deficiency is a risk factor for human colorectal cancer. He said: "In future clinical studies, a direct link between TRPV1 function and human colorectal cancer should be addressed."
However, if this is true, current research suggests that one potential treatment may be capsaicin, a stimulant of mammals that comes into contact with the tissue to create a burning sensation. Capsaicin has been widely used as an analgesic for topical ointments, which act as an overwhelming stimulant that prevents the nerves from prolonged pain. It is also the active ingredient of pepper spray.
Researchers fed caprine to mice genetically more prone to multiple gastrointestinal tumors. This treatment led to reduced tumor burden, extending the lifespan of mice by more than 30%. The treatment is more effective when used in combination with celecoxib (a COX-2 NSAID that has been approved for the treatment of some forms of arthritis and pain).
In a joint effort, researchers under the leadership of Dr. Mo Cheng Pa, of the State University of New York at Buffalo, and Dr. David Hill of the Lawson Health Institute and the University of Western Ontario in Canada, In the synthesis of enzymes - pyruvate dehydrogenase complex in mouse neonatal period how the regulation of islet β cell development and maturation.