biorelevant FaSSCoF_上海起发现货

• FaSSCoF is a biorelevant dissolution medium simulating human fasted state colonic fluid

• Assess how modified release drug products intended for colonic delivery dissolve in fluids in the fasted colon

FaSSCoF

FaSSCoF是一种模拟人类禁食状态结肠液的生物相关溶解介质

评估结肠给药的改性释放药物如何溶解在禁食结肠的液体中

Product Description

FaSSCoF is a biorelevant dissolution medium that simulates human fasted state colonic fluid. It contains the appropriate physiological components (bile salt and lipids) reflecting those present in colonic fluids before a meal. This makes FaSSCoF more predictive of solubility and dissolution than plain buffers.

It is used to assess how drugs and modified release drug products intended for colonic delivery dissolve in fasted state colonic fluids. In general, it is less useful for immediate release drugs because absorption of most immediate release drugs are largely complete when the colon is reached and the zone for absorption after oral administration is much smaller than the upper gastrointestinal tract. Here are the specific benefits of using this product:

*Ideal for use in USP dissolution apparatus (if using USP dissolution 1 or USP dissolution 2 apparatus we recommend 900ml of FaSSCoF per vessel)

*Drug analysis can be carried out by HPLC

*Simple and quick preparation method

*Get customized instructions explaining how to make different FaSSCoF volumes from our ‘Media Preparation Tool’ (see above)

产品描述

FaSSCoF是一种模拟人类禁食状态结肠液的生物相关溶解介质。它含有适当的生理成分（胆盐和脂质），反映了餐前结肠液中存在的成分。这使得FaSSCoF比普通缓冲液更能预测溶解度和溶解性。

它用于评估用于结肠递送的药物和改性释放药物产品如何溶解在禁食状态的结肠液中。一般来说，它对立即释放药物用处不大，因为当到达结肠时，大多数立即释放药物的基本上吸收，并且口服给药后的吸收区比上消化道小得多。以下是使用此产品的具体好处：

*非常适合在USP溶出装置中使用（如果使用USP溶出1或USP溶出2装置，我们建议每个容器900ml FaSSCoF）

*药物分析可以通过HPLC进行

*简单快速的制备方法

*从我们的“Media Preparation Tool”中获取解释如何制作不同FaSSCoF卷的定制说明（见上文）