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SPDP,CAS#68181-17-9,3-(2-吡啶基二硫基)丙酸N-羟基琥珀酰亚胺酯
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产品名称：SPDP
英文名称：N-Succinimidyl 3-(2-Pyridyldithio)propionate
中文名称：3-(2-吡啶基二硫基)丙酸N-羟基琥珀酰亚胺酯
CAS #: 68181-17-9
简介：SPDP crosslinker is a cleavable, water insoluble, amino and thiol (sulfhydryl) reactive heterobi-functional protein crosslinker. The SPDP crosslinking reagent's reactive moites consist of an N-hydroxysuccinimide (NHS) ester that reacts with primary amines. On the other end of SPDP, the pyridinyldisulfide reacts with sulhydryls to yield a reversible disulfide bond.
Application
3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester (SPDP) is useful for the preparation of enzyme immunoconjugates and hapten carrier molecule conjugates.
It has been used for antibody conjugation and as a protein cross-linker.
General description
3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester (SPDP) is a heterobifunctional cross-linking reagent with amine and sulfhydryl reactivity. It is typically coupled initially to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). Second coupling specific for molecules containing free sulfhydryl by thiol-disulfide exchange buffered at pH 8.0 (7.5-8.5). Alternay, this reagent may be used as a protected thiolating reagent following initial coupling and reduction of linker. It incorporates four atom linker.
外观：白色粉末
Molecular Weight: 312.4
分子式:C12H12N2O4S2
CAS #: 68181-17-9
溶解：DMSO or DMF
Spacer Length: 6.8 Å
Alternative Name: 3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester
纯度：98%+
保存：-20℃
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