产品信息

TGF-β家族成员广泛存在于从果蝇到人多种生物的 各种组织中，对正常细胞、癌变细胞都有着显著作用。TGF-β除了影响细胞的增殖、分化，还在胚胎发育、胞外基质形成、 骨的形成和重建等方面起着重要作用。

ALK-5
A selective inhibitor of ALK5 (TGF-beta type I receptor). It has also been shown that this compound can replace Sox2 when reprogramming cells to iPS cells. 2-(3-(6-METHYLPYRIDIN-2-YL)-1H-PYRAZOL-4-YL)-1,5-NAPHTHYRIDINE

Ref: Gellibert, F., et al. (2004) Identification of 1, 5-naphthyridine derivatives as a novel series of potent and selective TGF-beta type I receptor inhibitors. J Med Chem 47: 4494-4506. Ichida, J.K., et al. (2009) A small-molecule inhibitor of Tgf-beta signaling replaces Sox2 in reprogramming by inducing Nanog. Cell Stem Cell 5: 491-503

Purity:
Greater than 98% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request.

Biological Activity:Not determined.

重庆市华雅干细胞技术有限公司