LC R5000-现货|雷帕霉素|Rapamycin|AY22989|Sirolimus|西罗莫司|
LC Laboratories 品牌
代理商厂商性质
上海市所在地
*|PBDA|Alexis ALX-550-380-M005
¥3638*|MTEP|Alexis ALX-550-381-M005
¥1257原装*|MSDH-C|ALX-303-005-M001|CAS 144474-37-3
¥3241原装*|Vinyl-L-NIO|Alexis ALX-270-216-M025
¥4057TIQ-A|Alexis ALX-270-365-M005|原装*
¥3241原装*|Ac-YVAD-CHO|Alexis ALX-260-027-M005
¥2712S-(+)-CBPG;S-CBPG;ALX-550-323-M005 原装*
¥3241BPIQ-I;BPIQ I;ALX-270-313-M001;CAS 174709-30-9 *
¥3352IBTU;ALX-550-384-M001 原装*
¥1830Asterric acid;CAS 577-64-0;ALX-380-208-M001 zpjk
¥4366Z-VRPR-FMK|ALX-260-166-MC05|原装*
¥4631现货|Cholera Toxin|霍乱毒素|Cholergen
¥1985英文名: Sirolimus;Rapamycin;AY 22989;FRAP;FAFT
中文名: 雷帕霉素;西罗莫司
Rapamycin也称AY 22989或sirolimus,可与FKBP12形成复合物,随后结合并抑制FRAP/mTOR。mTOR是哺乳动物中rapamycin的作用靶点,也被称为FRAP或FAFT,是一个Ser/Thr蛋白激酶,可以激活p70 S6 kinase。Rapamycin对于p70 S6 kinase的抑制作用的IC50为0.05nM。Rapamycin通过抑制FRAP/mTOR可以抑制p70 S6 kinase的磷酸化和激活,抑制4E-BP1/PHAS1的磷酸化并促进其对eIF4E的结合和抑制。
LC Laboratories相关资料如下:
R-5000 Rapamycin, >99%
M.W. 914.17 C51H79NO13 [53123-88-9]
RTECS: VE6250000 M.I. 12: 8288 M.I. 14: 8114
Storage: Store at or below -20 ºC.
Solubility: Soluble in DMSO or ethanol (up to about 50 mg/mL for either solvent).
Disposal: A
View the MSDS for this product:
• Immunosuppressant, related to FK-506, but without calcineurin inhibitory activity even when complexed to FK-506 binding protein. Selectively blocks signaling that leads to p70 S6 kinase activation (IC50 = 50 pM). Terada, N., et al. "Failure of rapamycin to block proliferation once resting cells have entered the cell cycle despite inactivation of p70 S6 kinase." J. Biol. Chem. 268: 12062-12068 (1993). Fingar, D.C., et al. "Dissociation of pp70 ribosomal protein S6 kinase from insulin-stimulated glucose transport in 3T3-L1 adipocytes." J. Biol. Chem. 268: 3005-3008 (1993). Price, D.J., et al. "Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase." Science 257: 973-977 (1992). Chung, J., et al. "Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases." Cell 69: 1227-1236 (1992).
保存条件: -20度