Wnt通路抑制因子DKK-1检测试剂盒

背景介绍：

DKK-1是影响成骨细胞成熟的WNT信号通道的拮抗剂。Dkk-1 首先在人肝母细胞瘤和Wilms’瘤中，然后在肝肿瘤中被发现高表达。Dkk-1 的高表达被证明可以成为多种肿瘤预后差的标志，如肝细胞癌、食道癌、骨肉瘤、肺癌、结肠癌、骨关节炎、骨质疏松症、卵巢上皮癌和多发性骨髓瘤。DKK-1对肿瘤的骨转移有促进作用，这与DKK-1能导致骨吸收，抑制骨形成的作用相一致。

产品优势：

• 用于人血清样本检测
• 样本量小，只需20ul
• 检测范围宽
• 夹心法检测
• 操作时间短

参考文献：

• The role of Dickkopf-1 in bone development, homeostasis, and disease. Pinzone JJ et al., Blood, 2009; 113: 517-525.
• Elevated Serum Dickopf-1 Levels Increase Risk of Hip and Vertebral Fracture in Older Caucasian Women. Arasu A et al., Endocr Rev, 2013; 34: SAT-224.
• Comparative Effect of Zoledronic Acid Versus Denosumab on Serum Sclerostin and Dickkopf-1 Levels of Naive Postmenopausal Women With Low Bone Mass: A Randomized, Head-to-Head Clinical Trial. Anastasilakis AD et al., J Clin Endocrinol Metab, 2013; 98: 3206-3212.