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ω-Conotoxin-SO3 (ω-漏斗网蛛毒素SO3 )
面议ω-Conotoxin MVIIC / Omega conotoxin MVIIC (ω-漏斗网蛛毒
面议ω-Conotoxin MVIIA (ω-漏斗网蛛毒素MVIIA)
面议ω-conotoxin GVIA(ω-漏斗网蛛毒素GVIA)
面议ω-agatoxin IVA(ω-漏斗网蛛毒素 IVA)
面议Margatoxin(MgTx,玛格斑蝎毒素)
面议Kaliotoxin-1(卡利蝎毒素-1)
面议Jingzhaotoxin III(JZTx-III,敬钊缨毛蛛毒素-III)
面议Iberiotoxin 伊比(利亚)蝎毒素
面议Huwentoxin-IV(虎纹捕鸟蛛神经毒素-IV)
面议Huwentoxin-I(虎纹捕鸟蛛神经毒素-I)
面议Hainantoxin-IV(海南捕鸟蛛毒素-IV)
面议µ-conotoxin GIIIB(µ-芋螺毒素 GIIIB)
Selective blocker of Nav1.4 channels(钠离子通道Nav1.4选择性阻断剂)
µ-conotoxin GIIIB is a 22-mer peptide originally isolated from the venom of the piscivorous marine snail Conus geographus. µ-conotoxin GIIIB adopts a compact structure consisting of a distorted 310-helix and a small ß-hairpin. µ-conotoxin GIIIB is stabilized by three disulphide bridges and is highly enriched in lysine and arginine residues, forming potential sites of interaction with Na channels. An unusual feature is the presence of three hydroxyproline residues. µ-conotoxin GIIIB is a useful probe to discriminate between neuronal and muscle sodium channels as it exhibits at least a 1000-fold specificity for muscle versus nerve sodium channels. µ-Conotoxin GIIIB selectively blocks Nav1.4(µ1) voltage-dependent sodium channels, which are predominantly expressed in muscle, with an affinity close to 20 nM.µ-Conotoxin GIIIB appears to physically occlude the channel pore by binding on site I of the Na+ channel.
µ-conotoxin GIIIB 技术资料
氨基酸序列:
Arg-Asp-Cys3-Cys4-Thr-Hyp-Hyp-Arg-Lys-Cys10-Lys-Asp-Arg-Arg-Cys15-Lys-Hyp-Met-Lys-Cys20-Cys21-Ala-NH2
二硫键: Cys3-Cys15, Cys4-Cys20 and Cys10-Cys21
长度 (aa): 22
分子式: C101H175N39O30S7
分子量:2640.26 Da
外观:White lyophilized solid
可溶性:water and saline buffer
CAS 号:not available
来源: Synthetic
纯度:> 97 %
产品信息
CON020-50100 | µ-conotoxin GIIIB | 5x 0.01mg |
CON020-00100 | µ-conotoxin GIIIB | 0.1mg |
CON020-00500 | µ-conotoxin GIIIB | 0.5mg |
CON020-01000 | µ-conotoxin GIIIB | 1mg |