Kaliotoxin-1（卡利蝎毒素-1） 

Potent blocker of potassium channels(钾离子通道强阻断剂)

Kaliotoxin-1 (KTX1) has been isolated from the venom of the Scorpion Androctonus mauretanicus mauretanicus. Kaliotoxin-1 shows a high structural affinity with  Iberiotoxin and Charybdotoxin that inhibit K_Ca²⁺ channels activity. According to several studies, it appears that Kaliotoxin-1 has a weak inhibitory effect on K_Ca²⁺ channels, but it is a potent and selective inhibitor of voltage-activated potassium channel (K_v1.1, K_v1.2, K_v1.3).

Kaliotoxin-1 技术资料

氨基酸序列：

Gly-Val-Glu-Ile-Asn-Val-Lys-Cys⁸-Ser-Gly-Ser-Pro-Gln-Cys¹⁴-Leu-Lys-Pro-Cys¹⁸-Lys-Asp-Ala-Gly-Met-Arg-Phe-Gly-Lys-Cys²⁸-Met-Asn-Arg-Lys-Cys³³-His-Cys³⁵-Thr-Pro-Lys-OH 

二硫键： Disulfide bonds between Cys⁸-Cys²⁸, Cys¹⁴-Cys³³ and Cys¹⁸-Cys³⁵ 

长度 (aa)：38 

分子式：C₁₇₁H₂₈₃N₅₅O₄₉S₆ 

分子量：4149.89 Da 

外观： White lyophilized solid 

可溶性： water and saline buffer 

CAS 号：not available 

来源：  Synthetic  

纯度：> 97 % 

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