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匹伐他汀杂质列表

时间:2017-02-23      阅读:3077

匹伐他汀杂质列表  深圳远扬化学技术有限公司主营医药标准品及杂质对照品,以下杂质备有库存,可当天发货,*:匹伐他汀杂质,曲氟尿苷杂质,依鲁替尼杂质,奥贝胆酸杂质,依美斯汀杂质,卡格列净杂质,利格列汀杂质,西格列汀杂质,埃索美拉唑杂质,LCZ696杂质,恩杂鲁胺杂质,艾曲波帕杂质,非布司他杂质,托匹司他杂质,乐伐替尼杂质,奥拉帕尼杂质,阿维巴坦杂质,奥美拉唑杂质,普卡必利杂质,西他沙星杂质,泊沙康唑杂质,替格瑞洛杂质,托法替尼杂质,决奈达隆杂质,阿奇霉素杂质等。

 

匹伐他汀钙背景及前程:

冠心病是威胁人类健康和生命的常见病和多发病,以低密度脂蛋白(LDL)升高为特征的高胆固醇血症则是诱发冠心病的主要危险因子之一。常用的降血脂药如烟酸类、树脂类或贝特类等疗效都难尽人意,降脂作用的是被称为他汀类(statins)的药物。他汀类药物共同的作用机制是都属于3—羟—3—甲基—戊二酰辅酶A(HMG—CoA)还原酶抑制剂,目前在世界广泛应用的主要有6种:洛伐他汀(lovastatin),普伐他汀(pravastatin),辛伐他汀(simvastatin),西立伐他汀(cerivastatin),氟伐他汀(fluvastatin)和阿托伐他汀(atorvastatin)。而近期由Kowa公司开发的新型他汀类药物匹他伐他汀钙,因其良好的降胆固醇作用而被称为“超级他汀类药物”(Superstatin)。

 

匹伐他汀杂质列表(具体结构式见附件)

若列表中无您需要的杂质,欢迎详询我司,我司可提供杂质定制服务,货期短,到货快

Pitavastatin

(+)-Monocalcium bis{(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-3,5-dihydroxy-6-heptenoate}

Pitavastatin Impurity 1

(3R,6E)-7-[2-cyclopropyl-4-(4-flurophenyl)-3-quinolinyl]-3-hydroxy-5-oxo-6-heptenoate

Pitavastatin Impurity 2

(3S,5R,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl) quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid calcium salt

Pitavastatin Impurity 3

(4R,6S,E)-6-[2-[2-Cyclopropyl-4-(4-fluorophenyl) quinolin-3-yl] vinyl] tetrahydro-4-hydroxypyran-2-one

Pitavastatin Impurity 4

7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic Acid

Pitavastatin Impurity 5

(3R,5R,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl) quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid calcium salt

Pitavastatin Impurity 6

(3S,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl) quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid calcium salt

Pitavastatin Impurity 7

(3R,5S,6E)-7-[2-Cyclopropyl-4-phenyl-quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid calcium salt

Pitavastatin Impurity 8

 [[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]methyl]triphenyl-phosphonium Bromide

Pitavastatin Impurity 9

(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl]-2,2-dimethyl-1,3-dioxane-6-heptenoic acid t-butyl ester

Pitavastatin Impurity 10

(3R,5S,E)-7-(2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxy-N-(1-phenylethyl)hept-6-enamide

Pitavastatin Impurity 11

Sodium (5S, 6E)-7-[2-cyclopropyl-4-(4-flurophenyl)-3-quinolinyl]-5-hydroxy-3-oxo-6-heptenoate

Pitavastatin Impurity 12

Ethyl (3R, 6E)-7-[2-cyclopropyl-4-(4-flurophenyl)-3- quinolinyl]-3-hydroxy-5-oxo-6-heptenoate

Pitavastatin Impurity 13

Ethyl (5S, 6E)-7-[2-cyclopropyl-4-(4-flurophenyl)-3-quinolinyl]-5-hydroxy-3-oxo-6-heptenoate

Pitavastatin Impurity 14

(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid methyl ester

Pitavastatin Impurity 15

(3R,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl) quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid ethyl ester

Pitavastatin Impurity 16

(3R,5S)-5-(6-Cyclopropyl-10-fluoro-7,8-dihydrobenzo[k]phenanthridin-8-yl)-3,5-dihydroxypentanoic acid sodium salt

Pitavastatin Impurity 17

2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinemethanol

Pitavastatin Impurity 18

(3R,5R,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl) quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid ethyl ester

Pitavastatin Impurity 19

(3S,5R,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl) quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid ethyl ester

Pitavastatin Impurity 20

(3S,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl) quinolin-3-yl]-3,5-dihydroxyhept-6-enoic acid ethyl ester

Pitavastatin Impurity 21

(3R,5S,6E)-7-(2-Cyclopropyl-4-phenyl-3-quinolinyl)-3,5-dihydroxy-6-heptenoic Acid tert-Butyl Ester

Pitavastatin Impurity 22

2-((4R,6S)-6-((E)-2-(2-Cyclopropyl-4-phenylquinolin-3-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic Acid tert-Butyl Ester

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