Biochem/physiol Actions

CRANAD 2 is a near-infrared (NIR) Aβ plaque-specific fluorescent probe. CRANAD 2 penetrates the blood brain barrier and has a high affinity for Aβ aggregates with a Kd of 38 nM. Upon interacting with Aβ aggregates, exhibits a 70-fold increase in fluorescence intensity accompanied by a 90 nm blue shift from 805 to 715 nm and a large increase in quantum yield. has been used to detect Aβ deposits noninvasively in vivo in transgenic Tg2576 mice.

CAS:1193447-34-5

• 中文名称：CRANAD-2

• 英文名称：CRANAD-2

• 英文别名：(T-4)-[(1E,6E)-1,7-bis[4-(dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-kO3,kO5]difluoro-boron

• CAS号：1193447-34-5

• 分子式：C23H25BF2N2O2

• 分子量：410.26500

• 精确质量：410.19800

• PSA：32.78000

• LogP：4.93870

• 外观与性状：深蓝色或黑色粉末

• 可溶性：DMSO: soluble 0.2 mg/mL, clear (warmed)