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代理商厂商性质
北京市所在地
类器官Hydrocortisone
类器官（Organoids）是指将成体干细胞或多能干细胞在体外三维培养形成的具有一定空间结构的组织类似物。类器官在组织结构、细胞类型、自我更新能力和功能等方面与来源组织高度一致，从而在发育生物学、疾病造模、精准医学、药物研发、基因和细胞疗法、感染和免疫以及再生医学等生物医学的多个领域展现出*的优势。
产品介绍
DESCRIPTION
| Background | Hydrocortisone is a steroid hormone or glucocorticoid secreted by the adrenal cortex[1]. | ||
| Alias | Cortisol；氢化可的松；17-羟基皮质 (甾) 酮；皮质甾醇；氢化皮质素 | ||
| M. W t | 362.46 | ||
| Formula | C21H30O5 | ||
| CAS No | 50-23-7 | ||
| Storage | Powder | -20 °C | 3 years |
| In solvent | -80 °C | 6 months | |
| -20 °C | 1 month | ||
| Solubility | DMSO H2O : < 0.1 mg/mL | ≥ 31 mg/mL(85.53 mM) | |
| Ethanol | 23 mg/mL(63.46 mM) | ||
| H2O | < 0.1 mg/mL(insoluble) | ||
BIOLOGICAL ALTIVITY
In Vitro
Hydrocortisone (50 nM) shows a dose-dependent down-regulation of GR transcript in hCMEC/D3 cells. Hydrocortisone supplementation of the serum-reduced cell differentiation medium leads to a significant increase in TER across the hCMEC/D3 monolayer[1]. Hydrocortisone-treated Dendritic cells (DCs) show a decreased expression of MHC II molecules, the costimulatory molecule CD86, and the DC-specific marker CD83, as well as a strongly reduced IL-12 secretion. Hydrocortisone-treated DCs inhibit production of IFN-γ but induce an increased release of IL-4 and no change in IL-5[2]. Hydrocortisone reduces postischemic oxidative stress, perfusion pressure, and transudate formation. Hydrocortisone inhibits postischemic shedding of syndecan-1, heparan sulfate, and hyaluronan as is release of histamine from resident mast cells[3].
In Vivo
| NCT00621985 | Boston Children´s Hospital | Adrenal Hyperplasia, Congenital | Phase 2 |
| NCT03910088 | Cairo University | Post-Dural Puncture Headache | Phase 4 |
| NCT00657306 | University of Turin, Italy | Cirrhosis With Ascites | Phase 2 |
类器官Hydrocortisone
