软骨表面等3D压痕映射和厚度测试分析

时间：2020-10-28 阅读：460

多载荷多物理场耦合微观力学性能原位测试系统

之软骨表面等3D压痕映射和厚度测试分析

该系统模块化集成压缩、张力、剪切、摩擦、扭转和2D/3D压痕、3D轮廓及多力混合耦连测试的一体化微观力学测试装置。能对生物组织、聚合物、凝胶、生物材料、胶囊、粘合剂和食品进行精密可靠的机械刺激和表征。允许表征的机械性能包括刚度、强度、模量、粘弹性、塑性、硬度、附着力、肿胀和松弛位移控制运动。

压痕功能特性：

1、适用样品范围广：

1.1、从骨等硬组织材料到脑组织、眼角膜等软组织材料

1.2、从粗椎间盘的样品到j细纤维丝

2、通高量压痕测试分析

◆无需表面平坦，可在不规则表面压痕

◆压痕同时可测量厚度信息

◆压痕不要求压缩轴垂直于样品表面对齐

◆红宝石压头，坚固不易断,使用成本低

◆样品不需要从组织中收集

◆组织的破坏小

◆维持被测材料的机械环境及其与周围材料的相互作用

◆自动mapping

◆亚微米分辨率

◆样品范围广：极软脑组织泡沫到陶瓷、金属

◆力范围广5pa到500Gpa

      ◆一台仪器即可进行从纳米到宏观尺度的压痕
      ◆从小位移（几纳米）到大位移（大50mm）的压痕
      ◆大载荷范围（从0.025mN 到 250N）以满足样品特性的要求
      ◆大载荷范围对测量粗糙表面尤为有用

◆可以在将样品浸入溶液中的情况下进行

2.1、三维法向压痕映射非平面样品整个表面的力学特性

2.2、48孔板高通量压痕测试分析

3、力-电测试类型齐全

模块化集成压缩、张力、剪切、摩擦、扭转、穿刺、摩擦和2D/3D压痕、3D表面轮廓、3D厚度等各种力学类型支持,微观结构表征及动态力学分析研究

4、高分辨率:

4.1、位移分辨率达0.1um

4.2、力分辨率达0.025mN

5、行程范围广：50-250mm

6、体积小巧、可放入培养箱内

7 、高变分辨率成像跟踪分析

8、多轴向、多力偶联刺激

9、活性组织电位分布测试分析

10、产品成熟，文献量达上千篇

背景介绍：

Biomomentum对传统压痕技术进行了改进和扩充，压痕时不要求压缩轴垂直于样品表面对齐，无需表面平坦，即可在不规则表面压痕全自动压痕mapping和厚度测试mapping（压痕通常要求被测试的表面是平坦的，并且还需要垂直于关节表面的压缩轴）：
该MACH-1 V500 CSS的3D“正常压痕”函数检测XY位置处的表面高度和方向，并记录载荷（多轴向载荷单元），同时以不同速度移动测试仪的三个轴平台，以便以预定义的方式移动球形压头。沿着垂直于样品表面的虚拟轴的位移分布。利用该系统*的多轴能力、数字图像相关（Digital Image Correlation,DIC）测量全场应变广泛应用于组织材料力学、断裂力学、微观纳米应变测量、各种新型材料测量，允许压痕测试的所有点，同时克服了传统压痕的局限性。

纤维丝张力和扭力测

自动法向压痕和厚度映射

胫骨三维轮廓测试

机电活性材料（如结缔组织、带电水凝胶等）压缩过程中电位分布

英文描述：

软骨力学特性其他案例：

3D法向压痕测试典型文献参考

Sensitivity of indentation testing to step-off edges and interface integrity in cartilage repairBae W, Law A, Amiel D and Sah RAnn Biomed Eng, 32(3), 360-369. (2004)

Changes in Free Calcium Alter the Mechanical Properties of the Intervertebral DiscI. Hadjab, M.P. Grant, L.M. Epure, M. Garon, E. Quenneville, J. Anthoniou, F. Mwale and M.D. BuschmannInternational Conference on the Mechanics of Biomaterials and Tissues, Hawaii, USA, 1 2 Dec 2017, Podium O.48. Presented by E. Quenneville

The effect of in vivo chondrocyte depletion on the structural and functional properties of murine articular cartilageA.O. Masson, J.M. Corpuz, W.B. Edwards and R.J. KrawetzOsteoarthritis and Cartilage, April 2019, Volume 27, Supplement 1, Page S80

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Setting up a pre-clinical human model for mechanical induced osteoarthritis to investigate potential pharmacological agentsE. Houtman, M. van Hoolwerff, R. Coutinho De Almeida, A. Rodriguez Ruiz, N. Lakenberg, H.E. Suchiman, M. Tuerlings, R.G. Timmermans, R.G. Nelissen, Y.F. Ramos and I. MeulenbeltOsteoarthritis and Cartilage, April 2019, Volume 27, Supplement 1, Pages S80–S81.

Moderate exercise prevents cartilage softening and muscle structural changes in a rat model of obesityJ.L. Rios, J.W. Mather, J. Michaiel, S.M. Mattiello and W. HerzogOARSI Journal, April 2019 Volume 27, Supplement 1, Page S155

Bottlebrush polymer compositions, lubricating fluid, porous materials comprising said compositions, and surface bearing said compositionsX. Banquy, J. Faivre, B.R.Shrestha, K. Matyjaszewski, J.Burdynska and F. MoldovanUS Patent App. 16/095,051, 2019

A Col1a2 Mutation Reveals Bone Fragility, Hyperelasticity of Skin and Degeneration of Articular Cartilage in MiceS. Sim, A. Blease, M. Garon, E. Quenneville and P. PotterPoster SUN-053. American Society for Bone and Mineral Research, 22 Sep 2019, Orlando, Florida, USA

Biomechanical characterization of tibial articular cartilage in Hyp mice, a murine model of osteoarthritis in X-linked hypophosphatemiaMichael J. Desimone, Steven M. Tommasini, Christopher Cape and Carolyn M. MacicaPoster SUN-929. American Society for Bone and Mineral Research, 22 Sep 2019, Orlando, Florida, USA

Automated Indentation of Femoral and Temporomandibular Joints for Characterization of Cartilage Tissue Quality in Fgf2 KO Mice.Tannin SchmidtPoster SAT-996. American Society for Bone and Mineral Research, 21 Sep 2019, Orlando, Florida, USA

Viscoelasticity and histology of the human cartilage in healthy and degenerated conditions of the kneeMichael Seidenstuecker, Julius Watrinet , Anke Bernstein, Norbert P. Suedkamp , Sergio H. Latorre Anastasija Maks and Hermann O. MayrJournal of Orthopaedic Surgery and Research, November 2019, 14:256. DOI: 10.1186/s13018-019-1308-5

Bioinspired lubrication: from fundamentals to joint protectionX. Banquy, J. Faivre, G. Xie, K. Matyjaszewski, T. Delair, L. David, J. Burdynska, F. Moldovan, S. Benayoun, B. ShresthaICoBT, Montreal, Canada, September 27 2018. Oral presentation S8.1.

Quantifying the Effects of Different Treadmill Training Speeds and Durations on the Health of Rat Knee JointsRios, Jaqueline Lourdes; Boldt, Kevin Rudi; Mather, James William; Seerattan, Ruth Anne; Hart, David Arthur; Herzog, WalterSports Medicine - Open 2018 4:15

Investigating the role of in vivo cell cycle activation within mesenchymal stem cells in the regenerative potential of articular cartilage after injuryMasson, A. O.; Underhill, T. M.; Edwards, W. B.; Krawetz, R. J.Osteoarthritis and Cartilage 26 (2018) S38

Glycation marker glucosepane increases with the progression of osteoarthritis and correlates with morphological and functional changes of cartilage in vivoLegrand, Catherine; Ahmed, Usman; Anwar, Attia; Rajpoot, Kashif; Pasha, Sabah; Lambert, Cecile; Davidson, Rose K.; Clark, Ian M.; Thornalley, Paul J.; Henrotin, YvesArthritis Research & Therapy 2018 20:131

Contrast-Enhanced Computed Tomography (CECT) attenuation is associated with stiffness of intact knee cartilageNickmanesh, Reza; Stewart, Rachel C.; Snyder, Brian D.; Grinstaff, Mark W.; Masri, Bassam A.; Wilson, David R.J. Orthop. Res. First published: 17 April 2018 doi:10.1002/jor.24022

Automated Indentation Mapping of Vocal Fold Structure and Cover Properties across SpeciesGregory R. Dion, MD, Jean-Francois Lavoie, PhD, Paulo Coelho, DDS, PhD, Milan R. Amin, MD, Ryan C. Branski, PhDLaryngoscope. 2018 Nov 8. doi: 10.1002/lary.27341

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Electromechanical probe and automated indentation maps are sensitive techniques in assessing early degenerated human articular cartilageSim S, Chevrier A, Garon M, Quenneville E, Lavigne P, Yaroshinsky A, Hoemann CD and Buschmann MDJ Orthop Res, 35(4) 858-867. (2017) Epub 2016 Jun 22

Combined Mechanical Characterizations Increases Sensitivity in the Assessment of Human Cartilage DegenerationSim S, Hadjab I, Chevrolat L-A, Masse M, Tong AL, Lavigne P, Garon M, Quenneville E and Buschmann MDAccepted for a podium presentation at ORS 2017

Indentation and Thickness Mapping of Articular Surfaces through Manual Positioning (Protocol Template AAAX1 v1) Biomomentum Inc. Laval (QC), Canada, Effective Date: December 6th, 2016.

Mach-1 Analysis - Extraction of Elastic Model Parameters Following an Automated Indentation Mapping (SW186-SOP01-D v1)Sim S and Quenneville EBiomomentum Inc. Laval (QC), Canada, Effective Date: April 17th, 2015

Mach-1 – Automated Indentation Mapping (MA056-SOP01-D v2)Sim S and Quenneville EBiomomentum Inc. Laval (QC), Canada, Effective Date: April 7th, 2015

Guidelines for an optimized indentation protocol for measurement of cartilage stiffness - The effects of spatial variation and indentation parametersMoshtagh PR, Pouran B, Korthagen NM, Zadpoor AA and Weinans HJournal of Biomechanics 49(14) · September 2016 DOI: 10.1016/j.jbiomech.2016.09.020

Ermittlung mechanischer Kennwerte mittels IndentationSeidenstucker MBioNanoMat. 2015; 16 (2-3): 152–156 DOI 10.1515/bnm-2015-9014

Evaluation of a novel technique to map the mechanical properties of an entire articular surface in indentationSim S, Quenneville E, Garon M, Hoemann CD, Hurtig M and Buschmann MDInternational Cartilage Repair Society (ICRS), Turkey, 2013, Podium presentation (11.2.9)

Novel Technique to Map the Biomechanical Properties of Entire Articular Surfaces Using Indentation to Identify Osteoarthritis-like RegionsSim S, Chevrier A, Garon M, Quenneville E and Buschmann MDTransactions of the 60th Annual Meeting of the Orthopaedic Research Society, 2014, New Orleans, LA, USA, 2015, Poster #2015

Correlation of Non-destructive Electromechanical Probe (Arthro-BST) Assessment with Histological Scores, Biochemical Composition and Mechanical Properties in Human Knee JointsSim S, Chevrier A, Quenneville E, Garon M and Buschmann MDTransactions of the 60th Annual Meeting of the Orthopaedic Research Society, New Orleans, LA, USA, Poster 0439, 2014

Cartilage Stiffness and Thickness Distributions Revealed by an Automated Indentation Technique in the Temporomandibular JointSim S, Matuska A, Garon M, Quenneville E, McFetridge P and Buschmann MDTMJ Bioengineering Conference - V, September 12-13, 2016, Barcelona, Spain

Development of a Sequence of Mechanical Tests for Articular Cartilage at a Single LocationSim S, Chartrand A, Lavallee AP, Tessier J, Garon M, Quenneville E and Buschmann MDOrthopeadic Research Society Annual Meeting in Orlando, 2016

Wound Healing Revealed by a Novel Automated Indentation TechniqueSim S, Garon M, Quenneville E and Buschmann MDCanadian Connective Tissue Conference 2015 in Quebec, Canada

Evaluation of Entire Ovine Cartilage Repair Articular Surfaces: Mechanical and Electromechanical AssessmentSim S, Hadjab I, Garon M, Quenneville E, Hurtig MB, Buschmann MD and Hoemann CDTransactions of International Cartilage Repair Society (ICRS), Chicago, 2015, 7-11 May 2015, e-Poster: P87

Relevance of the Spatial Distribution of Mechanical Properties of Articular Cartilage in Animal StudiesSim S, Hadjab I, Garon M, Quenneville E, and Buschmann MDOrthopeadic Research Society Annual Meeting in Las Vegas, 2015, Poster 0359

Indentation Method to Map Mechanical Properties of Articular Surface to Identify Degenerated RegionsSim S, Chevrier A, Garon M, Quenneville E and Buschmann MD2014 Annual Meeting of the Biomedical Engineering Society, 2014, San Antonio, TX, USA. Podium presentation (ID: OP-Sat-3-4)

Novel Technique to Map the Biomechanical Properties of Entire Articular Surfaces Using Indentation to Identify Degenerated (Osteoarthritis-like) CartilageSim S, Chevrier A, Garon M, Quenneville E and Buschmann MD7th World Congress on Biomechanics, 2014, Boston, MA, USA. Poster 2229

Novel Technique to Map the Biomechanical Properties of Entire Mice Articular Surfaces Using IndentationSim S, Lavoie JF, Moreau A, Quenneville E, Garon M, and Buschmann MDOsteoarthritis and Cartilage, 22(1), 541. World Congress on Osteoarthritis, April 2014, Paris, France.

Growth Factor Stimulation Improves the Structure and Properties of Scaffold-Free Engineered Auricular Cartilage ConstructsRosa RG, Joazeiro PP, Bianco J, Kunz M, Weber JF, et alPLoS ONE 9(8): e105170. doi:10.1371/journal.pone.0105170. (2014)

Contrast-Enhanced Computed Tomography Reflects Stiffness of Intact Articular CartilageNickmanesh R, Stewart R, Snyder B, Grinstaff M and Wilson DISMRM Workshop on Imaging Based Measures of Osteoarthritis. Sept 11-14, 2015. Pacific Grove, CA, USA. Presentation on Sept 13 at 14:39.

Mapping Articular Cartilage Biomechanical Properties of Normal and Osteoarthritic Mice Using IndentationLavoie JF, Sim S, Quenneville E, Garon M, Moreau A, Buschmann MD and Aubin CEOsteoarthritis and Cartilage 23 Suppl. 2, p. A254 (2015)

Mapping Articular Cartilage Biomechanical Properties of Normal and Osteoarthritic Mice Using Indentation (OARSI Poster)Lavoie JF, Sim S, Quenneville E, Garon M, Moreau A, Buschmann MD and Aubin CEOsteoarthritis Research Society International (OARSI), 2015 April 30, Seattle, WA, United States

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Assessment of Human Articular Cartilage Issued from Asymptomatic & TKR DonorsHadjab I, Sim S, Quenneville E, Garon M and Buschmann MDBiomedical Engineering Society 2015 in Tampa, Floride

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Indentation probing of human articular cartilage: effect on chondrocyte viabilityBae W, Schumacher B and Sah ROsteoarthritis and Cartilage, 15(1), 9-18. (2007)

硬度微压痕测试文献

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Purpose: This procedure describes a standard method to realize an indentation hardness test on a material sample using the Mach-1 mechanical tester.

Scope: This procedure can be applied on any type of material with shape and dimension compatible with the specifications presented in the material section while the expected hardness results remain within tester..

ASTM E384 - Standard Test Method for Microindentation Hardness of Materials ASTM International, West Conshohocken, PA, 2016,

Significance and Use

5.1 Hardness tests have been found to be very useful for materials evaluation, quality control of manufacturing processes and research and development efforts. Hardness, although empirical in nature, can be correlated to tensile strength for many metals and alloys, and is also an indicator of machinability, wear resistance, toughness and ductility.

5.2...Read More

ASTM C1327 - Standard Test Method for Vickers Indentation Hardness of Advanced Ceramics ASTM International, West Conshohocken, PA, 2015,

刚度压痕测试文献

Sensitivity of indentation testing to step-off edges and interface integrity in cartilage repairBae W, Law A, Amiel D and Sah RAnn Biomed Eng, 32(3), 360-369. (2004)

Indentation probing of human articular cartilage: effect on chondrocyte viabilityBae W, Schumacher B and Sah ROsteoarthritis and Cartilage, 15(1), 9-18. (2007)

Novel Biomechanical Indentation Test Demonstrates Joint Surface Weakening in Mice Lacking Fibroblast Growth Factor Receptor 3 (FGFR3)Binette JS, Laflamme F, Li W, Valverde-Franco G, Tran-Khanh N, Quenneville E, Henderson JE and Buschmann MDPaper presented at the 11th Canadian Connective Tissue Conference, Montreal, QC, Canada. (2005)

Development and Validation of Large-Sized Engineering Cartilage Constructs in Full-Thickness Chondral Defects in a Rabbit ModelBrenner JMaster thesis Queen's University. (2012)

Association of 3-dimensional cartilage and bone structure with articular cartilage properties in and adjacent to autologous osteochondral grafts after 6 and 12 months in a goat modelChan EF, Liu IL, Semler EJ, Aberman HM, Simon TM, Chen AC, Truncale KG and Sah RLCartilage, 3(3), 255-266. (2012)

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3D压痕厚度测试文献

Sensitivity of indentation testing to step-off edges and interface integrity in cartilage repairBae W, Law A, Amiel D and Sah RAnn Biomed Eng, 32(3), 360-369. (2004)

Development and Validation of Large-Sized Engineering Cartilage Constructs in Full-Thickness Chondral Defects in a Rabbit ModelBrenner JMaster thesis Queen's University. (2012)

Assessment of Human Articular Cartilage Issued from Asymptomatic & TKR DonorsHadjab I, Sim S, Quenneville E, Garon M and Buschmann MDBiomedical Engineering Society 2015 in Tampa, Floride

Wound Healing Revealed by a Novel Automated Indentation TechniqueSim S, Garon M, Quenneville E and Buschmann MDCanadian Connective Tissue Conference 2015 in Quebec, Canada

Mach - Automated Thickness Mapping of an Articular Surface (MA056-SOP02-D v2)Sim S and Quenneville EBiomomentum Inc. Laval (QC), Canada, Effective Date: April 7th, 2015

Mach-1 Analysis - Extraction of Thickness Values Following Automated Thickness Mapping of an Articular Surface (SW186-SOP02-D v1)Sim S, Lavoie JF and Quenneville EBiomomentum Inc. Laval (QC), Canada, Effective Date: April 22th, 2015

The effect of in vivo chondrocyte dsepletion on the structural and functional properties of murine articular cartilageA.O. Masson, J.M. Corpuz, W.B. Edwards and R.J. KrawetzOsteoarthritis and Cartilage, April 2019, Volume 27, Supplement 1, Page S80

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多载荷多物理场耦合微观力学性能原位测试系统 之软骨表面等3D压痕映射和厚度测试分析

英文描述：

软骨力学特性其他案例：

3D法向压痕测试典型文献参考

多载荷多物理场耦合微观力学性能原位测试系统

之软骨表面等3D压痕映射和厚度测试分析