YP-Ab-00522-Siah-1/2 Polyclonal Antibody_多克隆抗体-天津俊达生物科技有限公司手机版

详细介绍

Siah-1/2 Polyclonal Antibody

抗体，也叫免疫球蛋白（Ig），是一种能特异性结合抗原的糖蛋白，而抗原是在易感染动物体内引发抗体产生的物质。在体内，抗体是由于外源性分子的侵袭而产生的。抗体以一个或者多个Y字形单体存在，每个Y字形单体由4条多肽链组成，包含两条相同的重链和两条相同的轻链。轻链和重链是根据它们的分子量大小来命名的。Y字形结构的顶端是可变区，为抗原结合部位。任何一个抗体的轻链都可以分为κ或λ型（基于小分子多肽结构上的差异），每一个抗体的重链则决定了它的类或型。

产品详情

Siah-1/2 Polyclonal Antibody detects endogenous levels of Siah-1/2 protein.

免疫原详细信息

The antiserum was produced against synthesized peptide derived from human SIAH1. AA range:181-230

相关试剂

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

背景

This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]

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产品简介

详细介绍

Siah-1/2 Polyclonal Antibody

常用功能直达