Epigentek 创新技术和表观遗传学-相关技术文章
时间：2024-07-17 阅读：92
Epigentek 创新技术和表观遗传学
Epigentek集团公司是全球创新技术和表观遗传学相关研究产品的开发商和供应商。公司开发了包括400多个产品的全面的产品组合，为表观遗传学方面的研究和新药研发提供全面系统的解决方案。2019年，Epigentek荣获“Bioz Rising Star TM ”,被评为2019表观遗传学领域的新星公司。
Epigentek公司的产品销售领域
全shi界的备受推崇的学者、制药企业以及很多专业的生物技术公司都在使用Epigentek产品。相比普通方法的产品而言，这些du特的产品在科研分析过程中更简单、更快捷、更方便、更有效。Epigentek公司的产品通过专门的销售队伍和遍布全球超过36个国家和地区的经销商进行销售。让客户满意和帮助客户在试验中取得最大成功是我们进行技术创新的首要任务。公司特别强调技术的速度和效率，继续侧重于表观遗传学创新和广泛发展，提高其产品组合。
Epigentek公司的产品类型
专业提供DNA甲基化试剂盒、组蛋白修饰相关试剂盒、染色质免疫沉淀反应试剂盒、基因表达与沉默检测试剂盒、DNA损伤及修复试剂盒、SUMO化修饰分析试剂盒、表型相关抗体等表观遗传学产品。
蛋白质与DNA之间的动态相互作用，参与并推动了基因的表达、调控、复制、重组和修复以及RNA的转运、翻译和调控等多个生物学过程，几乎涉及所有的生命活动。绘制这些蛋白质-DNA结合事件发生的时空关系，对于正常发育和疾病中表观遗传学的机理研究至关重要。
为了生成这种数据，科学家通常使用ChIP（染色质免疫沉淀）-Seq法。传统的ChIP-Seq实验需要花费三天来完成：首先进行染色质交联（使用甲醛作为交联剂），使基因组上分布的蛋白以及各种修饰定格下来，然后对交联的染色质进行超声裂解，再利用抗原抗体特异性反应将与目的蛋白相结合的DNA片段沉淀下来，再进行解交联释放结合蛋白的DNA片段，最后对获得的DNA片段进行测序分析。这些繁琐的步骤中会大量损失样本和信息，因此传统的ChIP-Seq方法具有需要大量细胞、重复性差、低信号、高背景等缺点。
2017年，Henikoff博士及其实验室的研究人员在eLife杂志上发表了一种称为CUT&RUN的新方法。CUT&RUN（Cleavage Under Targets and Release Using），即核酸酶靶向切割及释放技术。CUT&RUN技术的出现，克服了传统ChIP-seq方法的缺陷，可以在细胞天然染色质环境下进行蛋白-DNA互作的研究。
Epigentek公司的热销产品
产品名称 | 货号 | 规格 |
MethylFlash Methylated DNA 5-mC Quantification Kit (Colorimetric) | P-1034-96 | 96 Assays |
EpiQuik Total Histone Extraction Kit | OP-0006-100 | 100 Extractions |
EpiQuik Nuclear Extraction Kit | OP-0002-1 | 100 Assays |
BisulFlash DNA Modification Kit | P-1026-050 | 50 Reactions |
EpiQuik DNA Methyltransferase (DNMT) Activity/Inhibition Assay Kit | P-3001-1 | 48 Assays |
MethylFlash Methylated DNA 5-mC Quantification Kit (Colorimetric) | P-1034-48 | 48 Assays |
EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric) | P-9005-96 | 96 Reactions |
EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric) | P-9005-48 | 48 Reactions |
MethylFlash Hydroxymethylated DNA 5-hmC Quantification Kit (Colorimetric) | P-1036-96 | 96 Assays |
EpiQuik Chromatin Immunoprecipitation (ChIP) Kit | P-2002-1 | 24 Reactions |
Methylamp DNA Modification Kit | P-1001-2 | 80 Reactions |
MethylFlash Global DNA Methylation (5-mC) ELISA Easy Kit (Colorimetric) | P-1030-96 | 96 reactions |
MethylFlash Methylated DNA Quantification Kit (Fluorometric) | P-1035-96 | 96 Assays |
EpiQuik Plant ChIP Kit | P-2014-48 | 48 Reactions |
5-Methylcytosine (5-mC) Monoclonal Antibody [33D3] | A-1014-050 | 50 ug |
Methylamp Global DNA Methylation Quantification Ultra Kit | P-1014B-48 | 48 Assays |
Methylamp DNA Modification Kit | P-1001-1 | 40 Reactions |
Methylamp Global DNA Methylation Quantification Ultra Kit | P-1014B-96 | 96 Assays |
EpiQuik DNMT Activity/Inhibition Assay Ultra Kit (Colorimetric) | P-3009-48 | 48 Assays |
EpiQuik Plant ChIP Kit | P-2014-24 | 24 Reactions |
MethylFlash Hydroxymethylated DNA 5-hmC Quantification Kit (Colorimetric) | P-1036-48 | 48 Assays |
Methylamp Methylated DNA Capture (MeDIP) Kit | P-1015-48 | 48 Reactions |
EpiQuik 8-OHdG DNA Damage Quantification Direct Kit (Colorimetric) | P-6003-96 | 96 Assays |
Epigenase HDAC Activity/Inhibition Direct Assay Kit (Colorimetric) | P-4034-96 | 96 Assays |
EpiQuik Tissue Chromatin Immunoprecipitation (ChIP) Kit | P-2003-1 | 24 Reactions |
MethylFlash Hydroxymethylated DNA Quantification Kit (Fluorometric) | P-1037-96 | 96 Assays |
MethylFlash Methylated DNA Quantification Kit (Fluorometric) | P-1035-48 | 48 Assays |
EpiQuik Total Histone H3 Acetylation Detection Fast Kit (Colorimetric) | P-4030-96 | 96 Assays |
Methylamp Whole Cell Bisulfite Modification Kit | P-1016-80 | 80 Samples |
EpiQuik Total Histone H4 Acetylation Detection Fast Kit (Colorimetric) | P-4032-96 | 96 Assays |
EpiQuik DNA Methyltransferase (DNMT) Activity/Inhibition Assay Kit | P-3001-2 | 96 Assays |
EpiQuik Global Histone H3 Acetylation Assay Kit | P-4008-96 | 96 Assays |
Histone H3K9me3 (H3K9 Trimethyl) Polyclonal Antibody | A-4036-025 | 25 ul |
EpiQuik Chromatin Immunoprecipitation (ChIP) Kit | P-2002-2 | 48 Reactions |
EpiQuik HDAC Activity/Inhibition Assay Kit (Colorimetric) | P-4002-96 | 96 Assays |
EpiQuik MeDIP Ultra Kit | P-1052-48 | 48 Reactions |
5-Methylcytosine (5-mC) Monoclonal Antibody [33D3] | A-1014-010 | 10 ug |
EpiQuik DNMT Activity/Inhibition Assay Ultra Kit (Colorimetric) | P-3009-96 | 96 Assays |
EpiQuik Hydroxymethylated DNA Immunoprecipitation (hMeDIP) Kit | P-1038-24 | 24 Reactions |
EpiQuik Global Histone H4 Acetylation Assay Kit | P-4009-96 | 96 Assays |
EpiQuik One-Step DNA Hydrolysis Kit | P-1023-96 | 96 Samples |
EpiQuik Global Histone H3 Acetylation Assay Kit | P-4008-48 | 48 Assays |
EpiQuik Global Histone H4 Acetylation Assay Kit | P-4009-48 | 48 Assays |
5-Methylcytosine (5-mC) Monoclonal Antibody [33D3] | A-1014-100 | 100 ug |
Histone H3K9me2 (H3K9 Dimethyl) Polyclonal Antibody | A-4035-050 | 50 ul |
Histone H3K27me3 (H3K27 Trimethyl) Polyclonal Antibody | A-4039-025 | 25 ul |
EpiQuik Tissue Acetyl-Histone H3 ChIP Kit | P-2012-24 | 24 Reactions |
EpiQuik Dnmt1 Assay Kit | P-3011-2 | 48 Assays |
EpiQuik HAT Activity/Inhibition Assay Kit | P-4003-96 | 96 Assays |
EpiQuik Tissue Chromatin Immunoprecipitation (ChIP) Kit | P-2003-2 | 48 Reactions |