Resiniferatoxin

MCE 国际站：Resiniferatoxin

CAS：57444-62-9

品牌：MedChemExpress (MCE)

存储条件：-20°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

生物活性：Resiniferatoxin ((+)-Resiniferatoxin)，是一种选择性 TRPV1 受体激动剂，能够从 Euphorbia resinifera 植物中提取得到。在动物模型中，Resiniferatoxin 能够在相当长的一段时间内消除 TRPV1+ 初级感觉传入和钝性心脏交感传入反射。

体外：Resiniferatoxin 导致通道开放时间延长和钙内流，从而导致对 TRPV1 阳性疼痛纤维或细胞体的细胞毒性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内：Resiniferatoxin (2 μg/10 μl；鞘内注射到 T2/T3 间隙；冠状动脉闭塞后 4 周诱导大鼠心力衰竭) 显著和选择性地消除背角的传入标记物表达 (TRPV1 和降钙素基因相关肽) 并减少过度激活的 CSNA。Resiniferatoxin 显著逆转动作电位持续时间 (APD) 和 APD 交替的延长，降低室性心律失常的诱发性[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Clinical Trial

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研究领域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶点：TRP Channel

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参考文献：

[1]. Brown DC. Resiniferatoxin: The Evolution of the "Molecular Scalpel" for Chronic Pain Relief. Pharmaceuticals (Basel). 2016;9(3):47. Published 2016 Aug 11.[2]. Wu Y, et al. Resiniferatoxin reduces ventricular arrhythmias in heart failure via selectively blunting cardiac sympathetic afferent projection into spinal cord in rats. Eur J Pharmacol. 2020;867:172836.