Molecular Targeting Technologies国内代理Target Technology。Duramycin (Moli1901) 是一种来源于 Streptomyces cinnamoneuma 的羊毛硫细菌素。Duramycin 也是一种抗菌肽。Duramycin 可用于囊性纤维化（CF）的研究。荧光素CY5偶联Duramycin：Duramycin-Cy5 Fluorescent Conjugate（货号：D-1002），通过偶联荧光素，我们可以流式或者免疫荧光检测。甚至可以动态监测。
| 生物活性 | Duramycin (Moli1901) is a lantibiotic derived from Streptomyces cinnamoneuma. Duramycin also is a antimicrobial peptide. Duramycin can be used for the research of cystic fibrosis (CF). | ||||||||||
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| 体内研究 (In Vivo) | Evaluation of [68Ga]NODAGA-Duramycin as a positron emission tomography (PET) tracer of cell death for whole-body detection of chemotherapy-induced organ toxicity. Organ uptake is analyzed in untreated and doxorubicin, busulfan, and cisplatin-treated mice 2 h after intravenous injection of [68Ga]NODAGA-Duramycin. [68Ga]NODAGA-Duramycin PET/CT is successfully applied to non-invasively detect chemotherapy-induced organ toxicity with high sensitivity in mice. These methods are for reference only. | ||||||||||
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| 分子量 | 2013.28 | ||||||||||
| Formula | C89H125N23O25S3 | ||||||||||
| CAS 号 | 1391-36-2 | ||||||||||
| 性状 | 固体 | ||||||||||
| 外观颜色 | White to off-white | ||||||||||
| Sequence | Cys-Lys-Gln-Cys-Cys-Ala-Phe-Gly-Pro-Phe-{Abu}-Phe-Val-Cys-Asp-Gly-Asn-{Abu}-Lys-NH2 (Disulfide bridge: Cys1-Abu18, Cys4-Cys14, Cys5-Abu11) |
Product Description:
A Cy5 dye is attached to amino groups of duramycin. The conjugate contains 1 Cy5 dye molecule per duramycin molecule. Duramycin binds phosphatidylethanolamine (PE) at a 1:1 ratio with high affinity (Kd of 4-6 nM) and exclusive specificity. Properties of Duramycin-Cy5 。
Molecular Targeting Technologies荧光素CY5偶联Duramycin产品说明书
产品名称：Duramycin-Cy5 Fluorescent Conjugate
货号：D-1002
规格：132ugrams
代理：Targeting Technology（靶点科技）
溶解方法：
向小瓶中加入200uL 1%DMSO水溶液，用移液器上下吸液以溶解固体，得到就是250uM的含1%DMSO的水溶液。
