TRAIL/Apo2L抗体，*

           Anti- TRAIL/Apo2L抗体，*

From:ABCAM   

Catalog Number :RS-1214R

TRAIL/Apo2L抗体，*Quantity size :   0.1ml  （dilute with pH 7.4    0.01 M PBS or antibody diluent ） Background: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor （TNF） ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3.（tumor necrosis factor-related apoptosis-inducing ligand）
Function : Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
Subunit : Homotrimer.
Subcellular Location : Membrane; Single-pass type II membrane protein （Potential）.
Tissue Specificity : Widespread; most predominant in spleen, lung and prostate.
Similarity : Belongs to the tumor necrosis factor family.
Database links : UAnti-TRAIL/Apo2L is a rabbit polyclonal antibody             

specific for Anti-TRAIL/Apo2L of Human, Mouse, Rat,

use for western blotting,elisa,immunoprecipitation and immunohistochemistry

• Protein G affinity chromatography purification, purity :>95%
• Isotype:  IgG 
• mol wt:  31kDa

TRAIL/Apo2L抗体，*Application :  

• WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  Flow-Cyt=1:100-500  IF=1:100-500
• KLH conjugated synthetic peptide derived from human TRAIL C-terminus
• not yet tested in other applications.
• optimal dilutions/concentrations should be determined by the end user..

Storage:  Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The  lyophilized antibody is stable at room temperature for at least one month and for greater  than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent  of antibody, the antibody is stable for at least six weeks at 2-4 ℃

Important Note: This product as supplied is intended for research use only, not for use in  human, therapeutic or diagnostic applications.