文献名：A novel biodegradable amphiphilic diblock copolymers based on poly(lactic acid) and hyaluronic acid as biomaterials for drug delivery
作者：Chia Chang Liu1,2, Ken Yuan Chang1, Yng Jiin Wang2
1Biotech Division, Far Eastern Group R&D Center, Chung-Li, Taiwan, Republic of China
2Institute of Biomedical Engineering, National Yang Ming University, Taipei, Taiwan, Republic of China
摘要：An amphiphilic poly((lactic acid)-b-hyaluronic acid) diblock copolymer, poly(LA-b-HA), was synthesized from short-chain hyaluronic acid and poly(lactic acid). The synthesis was conducted by coupling the N, N′- dicyclohexylcarbodiimide activated poly(lactic acid) to a short-chain hyaluronic acid which was pre-aminated with 1, 2-ethylenediamine at the reducing end followed by NaCNBH3reduction. The poly (LA-b-HA) copolymers synthesized were verified by the spectral analyses of FTIR and 1H NMR. The poly(LA-b-HA) molecules can self-assemble into micelles in aqueous solution. The average diameters of polymeric micelles were estimated to be 116 ± 17 and 98 ± 11 nm for the polymeric micelles derived from the poly(lactic acid)s of MW 3,200 and MW 16,900, respectively. The poly(LA-b-HA) copolymeric material is non-cytotoxic and can be used as micellar drug carriers. The drug encapsulation capabilities of these poly(LA-b-HA) micelles were demonstrated by using ellagic acid and lidocaine chloride as model compounds. These new biodegradable micelles have a great potential to be used as drug delivery carrier for biomedical applications.
