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• 产品描述： Sal003 is a potent, specific and cell-permeable inhibitor of the eukaryotic translation initiation factor 2α (eIF2α) phosphatase. Sal003 is a derivative of salubrinal

• 靶点： eIF2α phosphatase

• 体内研究： Sal003 (20Μm; intrahippocampal injection; 8 minutes) impairs contextual memory in vivo

• 参考文献：
  1. Costa-Mattioli M, et al. eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory. Cell. 2007 Apr 6;129(1):195-206. 2. Yahiro K, et al. Regulation of subtilase cytotoxin-induced cell death by an RNA-dependent protein kinase-like endoplasmic reticulum kinase-dependent proteasome pathway in HeLa cells. Infect Immun. 2012 May;80(5):1803-14.

• 溶解度： DMSO  :  ≥  100  mg/mL  (215.88  mM)

• 保存条件： 2-8℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.163 ml	10.817 ml	21.635 ml
  5 mM	0.433 ml	2.163 ml	4.327 ml
  10 mM	0.216 ml	1.082 ml	2.163 ml
  50 mM	0.043 ml	0.216 ml	0.433 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的性，仅供客户参考交流研究之用。