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• 产品描述： Ramatroban is a selective thromboxane A2 (TxA2, IC50=14 nM) antagonist, which also antagonizes CRTH2 (IC50=113 nM) by inhibiting PGD2 binding.

• 靶点： hTP:14 nM (IC50);hDP2:113 nM (IC50);hDP2:33.4 μM (IC50)

• 体内研究： Ramatroban is an orally bioavailable small molecule antagonist of CRTH2. Systemic administration of Ramatroban (30 mg/kg) in CRTH2+/+ mice produces the same effects as seen in CRTH2 deficiency. Ramatroban completely blocks LPS-induced decreases in social and object exploratory behavior (p<0.01). in="" addition,="" tumor-impaired="" social="" interaction="" and="" object="" exploratory="" behavior="" in="" crth2+/+="" mice="" are="" completely="" reversed="" by="" a="" single="" injection="" of="" ramatroban,="" even="" when="" the="" tumor="" is="" enlarged="">

• 参考文献：
  1. Stearns BA, et al. Novel tricyclic antagonists of the prostaglandin D2 receptor DP2 with efficacy in a murine modelof allergic rhinitis. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4647-51. 2. Sugimoto H, et al. An orally bioavailable small molecule antagonist of CRTH2, ramatroban (BAY u3405), inhibits prostaglandin D2-induced eosinophil migration in vitro. J Pharmacol Exp Ther. 2003 Apr;305(1):347-52. 3. Haba R, et al. Central CRTH2, a second prostaglandin D2 receptor, mediates emotional impairment in the lipopolysaccharide and tumor-induced sickness behavior model. J Neurosci. 2014 Feb 12;34(7):2514-23.

• 溶解度： DMSO  :  125  mg/mL  (300.14  mM;  Need  ultrasonic)

• 保存条件： 2-8℃

• 配置溶液浓度参考：
  

  	1mg	5mg	10mg
  1 mM	2.401 ml	12.006 ml	24.012 ml
  5 mM	0.48 ml	2.401 ml	4.802 ml
  10 mM	0.24 ml	1.201 ml	2.401 ml
  50 mM	0.048 ml	0.24 ml	0.48 ml

• 注意：部分产品我司仅能提供部分信息，我司不保证所提供信息的性，仅供客户参考交流研究之用。