Anti-SLC27A6抗体,脂肪酸转运蛋白6抗体产品介绍：Acyl-coenzyme A synthetases (ACSs) are a large family of related enzymes known to catalyze the fundamental initial reaction in fatty acid metabolism. The ACS family is roughly characterized based on fatty acid chain length preference amongst different members. The nomenclature in the ACS family reflects this relationship and includes short-chain ACS (ACSS), medium-chain ACS (ACSM), long-chain ACS (ACSL) and very long-chain ACS (ACSVL). ACSVL family members are capable of activating both long (LCFAs) and very long-chain fatty acids (VLCFAs). There are six members of the human ACSVL subfamily, which have been described as solute carrier family 27A (SLC27A) gene products. They represent a group of evolutionarily conserved fatty acid transport proteins (FATPs) recognized for their role in facilitating translocation of long-chain fatty acids across the plasma membrane. The family nomenclature has recently been unified with their respective acyl-CoA synthetase family designations: ACSVL1 (FATP2), ACSVL2 (FATP6), ACSVL3 (FATP3), ACSVL4 (FATP1), ACSVL5 (FATP4) and ACSVL6 (FATP5). ACSVLs have unique expression patterns and are found in major organs of fatty acid metabolism, such as adipose tissue, liver, heart and kidney. ACSVL2 is a 619 amino acid multi-pass membrane protein. Encoded by a gene that maps to human chromosome 5q23.3, ACSVL2 may function as the predominant fatty acid protein transporter in heart.

功能区的作用：

（1）VL和VH：结合抗原决定簇（FV区）

（2）CL和CH：具有同种异型的遗传标记

（3）CH2：结合补体

（4）CH3：结合Fc受体

产品简介：

中文名称：脂肪酸转运蛋白6抗体

英文名称：Anti-SLC27A6 antibody

产品编号：BYK-9454R

别名：very long-chain 2; ACSVL2; FACVL2; FATP 6; FATP-6; FATP6; Fatty acid coenzyme A ligase, very long chain 2; Fatty acid transport protein 6; Fatty-acid-coenzyme A ligase; hVLCS H1; hVLCS-H1; Long-chain fatty acid transport protein 6; S27A6_HUMAN; SLC27A6; solute carrier family 27 fatty acid transporter member 6; Solute carrier family 27 member 6; Very long chain acyl CoA synthetase homolog 1; Very long-chain acyl-CoA synthetase homolog 1; VLCS H1; VLCSH1.  

脂肪酸转运蛋白6抗体*，主要应用于WB、IHC、IF、ELISA、流式细胞术等实验中。说明书随货发送，您也可以直接我司在线客服索取。客服

规格：0.1ml/0.2ml

浓度：1mg/1ml

抗体来源：本公司抗体有兔来源和鼠来源等

克隆类型：兔来源为多抗，鼠来源为单抗

产品类型：一抗

Anti-SLC27A6抗体保存条件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

避免反复冻融，保质期一年。

Anti-SLC27A6抗体,脂肪酸转运蛋白6抗体免疫应答

    抗原刺激机体产生相应的抗体，抗体的产生过程即为体液免疫应答过程。

    体液免疫应答的主要*位是淋巴结、脾脏和粘膜下淋巴组织等外周免疫器官，外来抗原进入机体后即被补体致敏或者被DC吞噬，然后随淋巴液进入引流淋巴结。淋巴滤泡中的FDC通过其表面的补体受体捕获被致敏的外来抗原，激活B细胞。位于脾髓质交界区的DC则为T细胞呈递外来抗原肽，启动获得性免疫应答，B细胞在外周成熟、发育过程的zui后阶段是成为专门的合成和分泌抗体分子的浆细胞。浆细胞高尔基体发达、代谢活跃，但没有继续分裂、增殖的能力，也不参与抗原递呈。他们寄居在脾脏或者骨髓中，集中所有的能量生产并分泌抗体分子。抗体分子的重链和轻链在内质网上合成、组装后经高尔基体运输至细胞表面并分泌于胞外。一个浆细胞每秒钟能分泌5000个抗体分子，在外周的浆细胞寿命仅为几天，但是骨髓中的浆细胞寿命可能较长。

     初次体液免疫是指宿主*次接触外来TD抗原后血清中逐渐出现抗原特异性抗体的过程。初次体液免疫应答的延迟相（从抗原免疫到抗体水平达到高峰的时间）为6-10天，起初几天血清中的抗原特异性抗体主要为亲和力较低的IgM,后期以IgG为主。初次应答过程的血清中抗原特异性抗体的高峰浓度较低且维持时间较短。再次体液免疫应答是指曾被某抗原免疫过的宿主再次接触该抗原时血清中迅速出现抗原特异性抗体的过程，其延迟相仅为4-5天，血清抗体以IgG为主，其高峰浓度较高且维持时间较长。再次应答所产生的抗体还有亲和力成熟现象，即该抗体与抗原的亲和力明显高于初次应答产生的抗体。

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