MCE 国际站：Trastuzumab emtansine
中文名：曲妥珠单抗-美坦新偶联物
CAS：1018448-65-1
品牌：MedChemExpress (MCE)
存储条件：Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性：曲妥珠单抗 emtansine (Ado-Trastuzumab emtansine) 是一种抗体药物偶联物 (ADC)，它结合了曲妥珠单抗的 HER2 靶向抗肿瘤特性和微管抑制剂 DM1（美登素的衍生物）的细胞毒活性. Trastuzumab emtansine可用于晚期乳腺癌的研究[1][2]。
体外：Trastuzumab emtansine (2 μg/mL; 3 d) 显着抑制上皮性卵巢癌 (EOC) 细胞的增殖[2]。
体内：Trastuzumab emtansine（15 mg/kg；每周静脉注射 3 至 5 次，持续 3 周）在小鼠体内表现出显着的抗肿瘤作用[2]。
热销产品：Masitinib | Potassium 1H-indol-3-yl sulfate | Ouabain (Octahydrate) | L-778123 (hydrochloride) | Romosozumab | CHAPS | 1,2-Distearoyl-sn-glycero-3-phosphorylcholine | Denosumab | Cobimetinib | N,N,N′,N′-Tetracyclohexyl-3-oxapentanediamide
研究领域：Antibody-drug Conjugate/ADC Related | JAK/STAT Signaling | Protein Tyrosine Kinase/RTK
作用靶点：Antibody-Drug Conjugates (ADCs) | EGFR
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
参考文献：
[1]. Verma S, et, al. Trastuzumab emtansine for HER2-positive advanced breast cancer. N Engl J Med. 2012 Nov 8;367(19):1783-91.
[2]. Menderes G, et, al. Superior in vitro and in vivo activity of trastuzumab-emtansine (T-DM1) in comparison to trastuzumab, pertuzumab and their combination in epithelial ovarian carcinoma with high HER2/neu expression. Gynecol Oncol. 2017 Oct;147(1):145-152.
