起订量:
Leica TCS SP8 激光扫描共聚焦显微镜
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代理商广州市炳阳生物科技有限公司是一家专注于生命科技领域的专业代理商和服务提供商。公司成立于2006年,拥有一个高专业素质的团队。炳阳公司秉承着“专业、诚信、创新、真挚”的精神,一路以来为广大客户提供*、*质的服务。
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我们的产品主要包括生命科学研究实验室设备、分析设备,主要代理品牌有:RaiDance,PLexera、ThermoFisher, Leica,C.T.L, ELGA, ESCO,贝瑞和康等国内外。
精选数字PCR仪、分子相互作用系统、二代测序、酶联斑点分析仪、单细胞分析仪等*、前沿的仪器设备。
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售前,我们的产品技术部由多名专业术员组成,凭着丰富的实验室经验和专业的角度,为客户提供技术解决方案。
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Leica TCS SP8 – 创新点概览
First publication on STED technology:
Hell, S. W. & Wichmann, J. Breaking the diffraction resolution limit by stimulated emission: stimulated-emission-depletion fluorescence microscopy. Optics letters 19, 780-782, (1994).http://www.ncbi.nlm.nih.gov/pubmed/19844443
First biological image:
Klar, T. A., Jakobs, S., Dyba, M., Egner, A. & Hell, S. W. Fluorescence microscopy with diffraction resolution barrier broken by stimulated emission. Proceedings of the National Academy of Sciences of the United States of America 97, 8206-8210, (2000). http://www.ncbi.nlm.nih.gov/pubmed/10899992
STED with genetically encoded marker: GFP
Willig, K. I. et al. Nanoscale resolution in GFP-based microscopy. Nature methods 3, 721-723, (2006).http://www.ncbi.nlm.nih.gov/pubmed/16896340
STED with continuous wave laser beams:
Willig, K. I., Harke, B., Medda, R. & Hell, S. W. STED microscopy with continuous wave beams. Nature methods 4, 915-918, (2007). http://www.ncbi.nlm.nih.gov/pubmed/17952088
Two-color STED with two STED lines
Donnert, G. et al. Two-color far-field fluorescence nanoscopy. Biophysical journal 92, L67-69, (2007).http://www.ncbi.nlm.nih.gov/pubmed/17307826
Iso-STED and two-color STED with one STED line
Schmidt, R. et al. Spherical nanosized focal spot unravels the interior of cells. Nature methods 5, 539-544, (2008).http://www.ncbi.nlm.nih.gov/pubmed/18488034
STED-FCS application
Eggeling, C. et al. Direct observation of the nanoscale dynamics of membrane lipids in a living cell. Nature 457, 1159-1162, (2009). http://www.ncbi.nlm.nih.gov/pubmed/19098897
Gated STED
Vicidomini, G. et al. Sharper low-power STED nanoscopy by time gating. Nature methods 8, 571-573, (2011).http://www.ncbi.nlm.nih.gov/pubmed/21642963
Selected Publications with Leica STED instrument
Qiu, Z. et al. Translation Microscopy (TRAM) for super-resolution imaging. Scientific reports 6, 19993, (2016).http://www.ncbi.nlm.nih.gov/pubmed/26822455
Ruge, C. A. et al. Disintegration of nano-embedded microparticles after deposition on mucus: A mechanistic study. Colloids and surfaces. B, Biointerfaces 139, 219-227, (2016). http://www.ncbi.nlm.nih.gov/pubmed/26720142
Scheuring, D. et al. Actin-dependent vacuolar occupancy of the cell determines auxin-induced growth repression. Proceedings of the National Academy of Sciences of the United States of America 113, 452-457, (2016).http://www.ncbi.nlm.nih.gov/pubmed/26715743
Torreno-Pina, J. A. et al. The actin cytoskeleton modulates the activation of iNKT cells by segregating CD1d nanoclusters on antigen-presenting cells. Proceedings of the National Academy of Sciences of the United States of America 113, E772-781, (2016). http://www.ncbi.nlm.nih.gov/pubmed/26798067