- 面议
起订量：
GSK2140944 Gepotidacin
- 型号
- GSK2140944
该企业相似产品
MedChemExpress (MCE) 专注于为科学家提供高品质的生物活性小分子化合物，化合物库及各类试剂盒，总部位于美国新泽西。
• MedChemExpress (MCE) 产品作用于 20 多个热门信号通路及研究领域的300多个细分靶点，拥有 10000 特异性抑制剂、激动剂，以及 50 活性化合物筛选库；
• 我们坚持对所有产品进行严格质检，确保产品的高品质和高纯度；
• MedChemExpress (MCE) 产品已被数万名科学家信赖，并被大量top文献和*引用；
• 我们拥有专业的技术团队追踪前沿科研进展，不断丰富各个靶点的特异性产品，坚持做 “您身边的抑制剂大师”；
• MedChemExpress (MCE) 与众多药企和科研机构保持深度合作；
• 大量产品有中国库存，工作日 16:00 前订单确保当日发货，次日送达。
MCE 中国站：www.MedChemExpress.cn
Hotline: 400-820-3792
Tel: 021-58955995
Email: sales@MedChemExpress.cn
Tech Support: 021-58950656
详细信息
Gepotidacin
产品活性：Gepotidacin (GSK2140944)是一种新型的三氮杂苊烯细菌II型拓扑异构酶抑制剂。
研究领域：Anti-infection
作用靶点：Bacterial
In Vitro: Gepotidacin is a novel, first-in-class, triazaacenaphthylene antibacterial that inhibits bacterial DNA gyrase and topoisomerase IV via a unique mechanism and has demonstrated in vitro activity against gram-negative and gram-positive bacterias , including drug-resistant strains, and also targets pathogens associated with other conventional and biothreat infections. The MIC50 and MIC90 for gepotidacin against the 25 N. gonorrhoeae isolates tested are 0.12 and 0.25 μg/mL, respectively. The gepotidacin MIC90s are as follows (in μg/mL): Streptococcus pyogenes, 0.25; Escherichia coli, 2; Moraxella catarrhalis, ≤0.06; Streptococcus pneumoniae, 0.25; Haemophilus influenzae, 1; Clostridium perfringens, 0.5; and Shigella spp., 1. Gepotidacin hasin vitroactivity against causative pathogens of acute bacterial skin and skin structure infections (ABSSSIs).
In Vivo: GSK2140944 MICs are 0.125 to 0.5 mg/L against the six MRSA isolates. ELF penetration ratios range from 1.1 to 1.4. Observed maximal decreases are 1.1 to 3.1 log10 CFU in neutropenic mice. The mean fAUC/MIC ratios required for stasis and 1-log-unit decreases are 59.3 ± 34.6 and 148.4 ± 83.3, respectively.
相关产品：Drug Repurposing Compound Library | Anti-Infection Compound Library | Clinical Compound Library | Clinical Compound Library Plus | Drug Repurposing Compound Library Plus | Bioactive Compound Library Plus | Puromycin Dihydrochloride | Tunicamycin | G-418 disulfate | Hygromycin B | Bleomycin sulfate | Vancomycin hydrochloride | Ampicillin sodium | Neomycin sulfate | Salinomycin | Avibactam sodium | Vaborbactam | Rifampicin | Minocycline hydrochloride | Bedaquiline | Carbenicillin disodium | Ciprofloxacin | Gentamicin sulfate | Metronidazole | Kanamycin sulfate | Methicillin sodium salt | Eravacycline dihydrochloride | Ceftazidime | Berberine chloride hydrate | Rimonabant Hydrochloride | Omadacycline hydrochloride | Chloramphenicol | Puromycin aminonucleoside | Tetracycline hydrochloride | Cefotaxime sodium salt
