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标准品 裸藻毒素PbTX-2/Brevetoxin B, PbTX-2
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详细信息
裸藻毒素PbTX-2/Brevetoxin B, PbTX-2
| Source: | Eupenicillium brefeldianum |
| Synonyms | Ascotoxin, Cyanein, Decumbin |
| Description: | A macrocyclic lactone from fungal source, exhibiting a wide range of antibiotic activity. |
| CAS number: | 20350-15-6 |
| Merck index: | 11, 1363 |
| Molecular weight: | 280.4 |
| Structure: |
|
| Molecular Formula: | C16H24O4 |
| Solubility information: | Methanol, Ethanol, Dichloromethane, DMSO, acetone or ethyl acetate |
| Specifications | |
| Appearance: | White to off-white crystalline solid. |
| Purity: | At least 98% by TLC |
| λmax: | |
| Melting point | 198°C-205°C |
| Solubility | Clear colorless solution at 10mg/ml Dichloromethane. Clear colorless solution at 10mg/ml Methanol. |
| Storage | -20°C |
| Applications | Inhibitor of protein translocation from endoplasmic reticulum （ER） to the Golgi apparatus. Inhibitor of intracellular protein transport and protein secretion |
| Warnings | TOXIC |
| Classification | macrocyclic lactone antibiotic. Antifungal Antiviral Protein Synthesis Inhibitor |
| Related products | |
| For Research use only. Not for Human or Drug use GMP/API grade available on request No genetically modified organisms are used. | |
| Publications | |
| Khine AA, Tam P, Nutikka A, Lingwood CA. Brefeldin A and filipin distinguish two globotriaosyl ceramide/verotoxin-1 intracellular trafficking pathways involved in Vero cell cytotoxicity. Glycobiology. 2004 Apr 21 | |
| Salles FT, Hespanhol AM, Jaeger RG, Marques MM. Brefeldin-A induces apoptosis in human adenoid cystic carcinoma cultured cells. Oral Oncol. 2004 Jul;40（6）:585-90. | |
| Padilla PI, Pacheco-Rodriguez G, Moss J, Vaughan M. Nuclear localization and molecular partners of BIG1, a brefeldin A -inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors. Proc Natl Acad Sci U S A. 2004 Mar 2;101（9）:2752-7. | |
| Mossessova E, Corpina RA, Goldberg J. Crystal structure of ARF1*Sec7 complexed with Brefeldin A and its implications for the guanine nucleotide exchange mechanism. Mol Cell. 2003 Dec;12（6）:1403-11. | |
| Togawa A, Ito H, Kimura F, Shimizu H, Ohtsuka M, Shimamura F, Yoshidome H, Katoh A, Miyazaki M. Establishment of gemcitabine-resistant human pancreatic cancer cells and effect of Brefeldin-A on the resistant cell line. Pancreas. 2003 Oct;27（3）:220-4. | |
| Vetterlein M, Niapir M, Ellinger A, Neumuller J, Pavelka M. Brefeldin A regulated retrograde transport into the endoplasmic reticulum of internalised wheat germ agglutinin. Histochem Cell Biol. 2003 Aug;120（2）:121-8. | |
| Lee MJ, Park JY, Lee SY, Lee JS, Jung DK, Bae YS, Kwak JY. Modulation of constitutive and delayed apoptosis by brefeldin A in human neutrophils. Int Immunopharmacol. 2003 Jun;3（6）:835-43. | |
| Campenot RB, Soin J, Blacker M, Lund K, Eng H, MacInnis BL. Block of slow axonal transport and axonal growth by brefeldin A in compartmented cultures of rat sympathetic neurons. Neuropharmacology. 2003 Jun;44（8）:1107-17. | |
| Pommepuy I, Terro F, Petit B, Trimoreau F, Bellet V, Robert S, Hugon J, Labrousse F, Yardin C. Brefeldin A induces apoptosis and cell cycle blockade in glioblastoma cell lines. Oncology. 2003;64（4）:459-67. | |
BJU International, Volume 271, Number 35, Issue of August 30, 1996 pp. 21604-21613 |
