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标准品 裸藻毒素PbTX-2/Brevetoxin B, PbTX-2

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详细信息

裸藻毒素PbTX-2/Brevetoxin B, PbTX-2

Source: Eupenicillium brefeldianum
Synonyms Ascotoxin, Cyanein, Decumbin
Description: A macrocyclic lactone from fungal source, exhibiting a wide range of antibiotic activity.
CAS number: 20350-15-6
Merck index: 11, 1363
Molecular weight: 280.4
Structure:

Brefeldin a

Molecular Formula: C16H24O4
Solubility
information:
Methanol, Ethanol, Dichloromethane, DMSO, acetone or ethyl acetate
Specifications
  
Appearance: White to off-white crystalline solid.
Purity: At least 98% by TLC
λmax:  
Melting point 198°C-205°C
Solubility Clear colorless solution at 10mg/ml Dichloromethane.
Clear colorless solution at 10mg/ml Methanol.
Storage -20°C
Applications Inhibitor of protein translocation from endoplasmic reticulum (ER) to the Golgi apparatus. Inhibitor of intracellular protein transport and protein secretion
Warnings TOXIC
Classification macrocyclic lactone antibiotic.
Antifungal
Antiviral
Protein Synthesis Inhibitor
Related products  
  For Research use only. Not for Human or Drug use
GMP/API grade available on request

No genetically modified organisms are used.
Publications  
  Khine AA, Tam P, Nutikka A, Lingwood CA.
Brefeldin A and filipin distinguish two globotriaosyl ceramide/verotoxin-1 intracellular trafficking pathways involved in Vero cell cytotoxicity.
Glycobiology. 2004 Apr 21
  Salles FT, Hespanhol AM, Jaeger RG, Marques MM.
Brefeldin-A induces apoptosis in human adenoid cystic carcinoma cultured cells.
Oral Oncol. 2004 Jul;40(6):585-90.
  Padilla PI, Pacheco-Rodriguez G, Moss J, Vaughan M.
Nuclear localization and molecular partners of BIG1, a brefeldin A -inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors.
Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2752-7.
  Mossessova E, Corpina RA, Goldberg J.
Crystal structure of ARF1*Sec7 complexed with Brefeldin A and its implications for the guanine nucleotide exchange mechanism.
Mol Cell. 2003 Dec;12(6):1403-11.
  Togawa A, Ito H, Kimura F, Shimizu H, Ohtsuka M, Shimamura F, Yoshidome H, Katoh A, Miyazaki M.
Establishment of gemcitabine-resistant human pancreatic cancer cells and effect of Brefeldin-A on the resistant cell line.
Pancreas. 2003 Oct;27(3):220-4.
  Vetterlein M, Niapir M, Ellinger A, Neumuller J, Pavelka M.
Brefeldin A regulated retrograde transport into the endoplasmic reticulum of internalised wheat germ agglutinin.
Histochem Cell Biol. 2003 Aug;120(2):121-8.
  Lee MJ, Park JY, Lee SY, Lee JS, Jung DK, Bae YS, Kwak JY.
Modulation of constitutive and delayed apoptosis by brefeldin A in human neutrophils.
Int Immunopharmacol. 2003 Jun;3(6):835-43.
  Campenot RB, Soin J, Blacker M, Lund K, Eng H, MacInnis BL.
Block of slow axonal transport and axonal growth by brefeldin A in compartmented cultures of rat sympathetic neurons.
Neuropharmacology. 2003 Jun;44(8):1107-17.
  Pommepuy I, Terro F, Petit B, Trimoreau F, Bellet V, Robert S, Hugon J, Labrousse F, Yardin C.
Brefeldin A induces apoptosis and cell cycle blockade in glioblastoma cell lines.
Oncology. 2003;64(4):459-67.
  Edward_B_Neufeld , Adele M. Cooney , Josef Pitha, Eliezar A. Dawidowicz , Nancy K. Dwyer, Peter G. Pentchev, E. Joan Blanchette-Mackie
Brefeldin A applications: Intracellular Trafficking of Cholesterol Monitored with a Cyclodextrin
BJU International, Volume 271, Number 35, Issue of August 30, 1996 pp. 21604-21613

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