褪黑素/Melatonin

Product Number: M5250
CAS Number: 73-31-4
MDL: MFCD00005655
Formula: C13H16N2O2
Formula Weight: 232.28 g/mol  

Appearance （Color） White to Off-White
Appearance （Form） Powder
Solubility （Color） Colorless to Faint Yellow-Brown
Solubility （Turbidity） Clear to Very Slightly Hazy
at 50 mg/ml in EtOH
Carbon 65.9 - 68.6 %
Nitrogen 11.8 - 12.4 %
Purity （TLC） >_ 98 %

Biochem/physiol Actions

Hormone; mediates photoperiodicity in mammals; inhibits cerebellar nitric oxide synthetase; peroxynitrite scavenger. Melatonin has complex effects on apoptotic pathways, inhibiting apoptosis in immune cells and neurons but enhancing apoptotic cell death of cancer cells. Inhibits proliferation/metastasis of breast cancer cells by inhibiting estrogen receptor action.

参考文献

Reiter, R.J., et al., Melatonin as a pharmacological agent against neuronal loss in experimental models of Huntington's disease, Alzheimer's disease and parkinsonism. Ann. N.Y. Acad. Sci. 890, 471-485, （1999） 摘要

Goldman, B.D., The circadian timing system and reproduction in mammals. Steroids 64, 679, （1999） 摘要

Cuzzocrea, S, et al., The protective role of endogenous melatonin in carrageenan-induced pleurisy in the rat. FASEB J. 13, 1930, （1999） 摘要

Sainz, R.M., et al., Melatonin and cell death: differential actions on apoptosis in normal and cancer cells. Cell. Mol. Life Sci. 60, 1407-1426, （2003） 摘要

Sanchez-Barcelo, E.J., et al., Melatonin and mammary cancer: a short review. Endocrinol. Relat. Cancer 10, 153-159, （2003）

Assayed, M.E., and Abd El-Aty, A.M., Protection Of Rat Chromosomes By Melatonin Against Gamma Radiation-induced Damage. Mol. Cell. 677, 14-20, （2009）

Welp, A., et al., Development And Validation Of A High Throughput Direct Radioimmunoassay For The Quantitative Determination Of Serum And Plasma Melatonin （N-acetyl-5-methoxytryptamine） In Mice. J. Immunol. Methods 358, 1-8, （2010） 摘要

Merck 14,5816

Beil. 22,V,12,42

FT-IR 2 （3）, 3606:D / FT-IR 1 （2）, 677:A / FT-NMR 1 （3）, 156:C / IR-Spectra （3）, 1260:A / IR-Spectra （2）, 1095:G / NMR-Reference 2 （2）, 546:C / RegBook 1 （2）, 2421:A / Sigma FT-IR 1 （1）, 678:D / Structure Index 1, 384:D:3