霍乱毒素B亚基抗体（cat#703）

Anti-Cholera Toxin B Subunit (Goat)

产品组成：
用100ul水重悬后，为含100ul抗霍乱毒素B亚基的山羊抗血清，加入了0.1%的NaN3用作抗体保护剂。
实验：
用该产品（依据批次而定）针对0.5mg/ml的霍乱毒素B亚基形成免疫沉淀条带的最大稀释度为：1:4。
产品保存：
无菌冻干粉，重悬前2-8℃保存。
防护：
操作时，请穿上实验服，带上手套和防护眼镜。此产品仅供科研应用，不可用于诊断试剂。

Cholera toxin is protein complex secreted by the bacterium Vibrio cholerae. CTX is responsible for the massive, watery diarrhea characteristic of cholera infection. The cholera toxin is an oligomeric complex made up of six protein subunits: a single copy of the A subunit (part A, enzymatic), and five copies of the B subunit (part B, receptor binding), denoted as AB5. Subunit B binds while subunit A activates the G protein which activates adenylate cyclase. The five B subunits - each weighing 11 kDa, form a five-membered ring. The A subunit which is 28 kDa, has two important segments. The A1 portion of the chain (CTA1) is a globular enzyme payload that ADP-ribosylates G proteins, while the A2 chain (CTA2) forms an extended alpha helix which sits snugly in the central pore of the B subunit ring. This structure is similar in shape, mechanism, and sequence to the heat-labile enterotoxin secreted by some strains of the Escherichia coli bacterium.