K200050M-Anti-EGFR Monoclonal Antibody_Monoclonal Antibody-北京索莱宝科技有限公司手机版

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Anti-EGFR Monoclonal Antibody

英文名称	Anti-EGFR Monoclonal Antibody
宿主	Mouse
别名	Epidermal growth factor receptor;erbb 1;Receptor tyrosine protein kinase ErbB 1
应用	WB IF IHC
稀释比例	WB 1:500-2000. IF 1:100-200. IHC 1:200-500.
交叉反应	Human
蛋白分子量	170kDa
Gene ID	1956
保存	Store at -20°C. Avoid freeze / thaw cycles.
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
纯化方法	Affinity purification
亚型	IgG1
免疫原	A synthetic peptide coupled to KLH
性状	液体
Public Immunogen Range	A synthetic peptide coupled to KLH
Subcellular Locations	Nucleus Endosome Plasma membrane Golgi apparatus Endoplasmic reticulum secreted
Swiss Prot	P00533
克隆号	1B1
克隆类型	Monoclonal Antibody
背景资料	The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascadesβ-Actin is one of six different actin isoforms that have been identified. The actin molecules found in cells of various species and tissues tend to be very similar in their immunological and physical properties. Therefore, Antibodies against β-Actin are useful as loading controls for Western Blotting. However it should be noted that levels of β-Actin may not be stable in certain cells. For example, expression of β-Actin in adipose tissue is very low and therefore β-Actin should not be used as loading control for these tissues.

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