DermiGen DermiGen Modified Tension Bioreactor,3D皮肤牵张应力加载培养分析仪(皮肤振荡拉伸压缩刺激生物反应器)对处于的空气—培养基界面的样本施加静态/振荡拉伸和压缩刺激。其应用范围包括细胞功能研究、组织工程构建物的生长和发育以及药物测试和再生疗法。DermiGen系统也可以实现用户自定义的应力/应变波形。

DermiGen生物反应器系统包括拉伸/压缩机械刺激。伺服电机配置整体干轴承，刺激器重量轻，结构紧凑，耐腐蚀，并且兼容大多数标准的孵化器。刺激器同时控制负载和位移，其紧凑的尺寸允许4刺激器和反应室单元适应标准的孵化器架。刺激器规格：

*        尺寸：72mm x420mm x 115mm  （ H x L x W ）

*        峰值力：44N

*        持续力：20N

*       重量：2.2kg

D70-1 DermiGen 生物反应器系统

D70-1 DermiGen系统被配置为一个单一的样品生物反应器系统，通过用户定义的刺激协议，能够支持广泛的细胞和组织生长实验。此系统可以定制特殊的研究应用。

·    样品长度：45 - 70 mm

·    样品厚度：0.1 - 2 mm

·    样品宽度：20 mm

D70-4 DermiGen 生物反应器系统

D70-4已被设计成一个多刺激的生物反应器系统。GrowthWorks软件/控制器操作4个独立的D70-1刺激器，以增加样品的测试能力。如同D70-1一样，此系统可以定制特殊的研究应用。

反应室

由生物惰性、高压灭菌的材料制成，DermiGen生物反应器室提供静态和振荡拉伸刺激。该反应室的*设计提供了一个空气/介质界面，以促进细胞共同培养和皮肤类样品的开发。反应室协助介质沿构建体底部灌注/流动，同时阻止介质溢到上部。一种*的密封件提供了一个机械馈道（真空密封通路）与反应室，同时以zui小的阻力在无菌环境中进行轴向运动。用带有柔软衬里的机械夹具保证样品的安全定位

ProductsDermiGen: Tension Bioreactor with Air/Media Interface

The DermiGen bioreactors impart static and oscillatory stimulation to a "skin like" sample in a unique air-to-nutrient media interface. Applications include investigating cell function and stimulating the growth and development of engineered tissues.  The device can also be used as a "test bed" for pharmaceutical and regenerative therapies. The DermiGen can apply either stress or strain using operator defined wave forms.

D70-1 DermiGen

The D70-1 system is configured as a single sample bioreactor system that is able to support a wide range of of cell and tissue growth experiments via user defined stimulating protocols.  The chamber's unique design provides an air/media interface to facilitate cell co-culture and the development of skin like products. The chamber provides media perfusion/flow along the underside of the construct while preventing it from migrating onto the topside.  Mechanical clamp grips with soft linings provide secure positioning of the sample. This chamber can accommodate a single sample with a maximum length of 45-70mm, 20mm width  and 0.1 to 2mm thickness. The instrument may be customized to specific research applications.

D70-4 DermiGen

The D70-4 DermiGenhas been designed as a multi-stimulator bioreactor system. The GrowthWorks Software/Controller operates four (4) independent D70-1 Stimulators to provide increased sample capabilities. As with the D70-1, these instruments may be customized for specific research applications.

GrowthWorks® Software & Control:

The GrowthWorks Software and Control platform includes advanced capabilities, such as multiple waveform control, data acquisition and multi-motor operation. The intuitive software runs on a Windows® laptop computer and features a simple user interface. User defined stimulation profiles are controlled by the software and are readily monitored using graphical displays. Integrated data acquisition routines capture and record data at user prescribed intervals. The GrowthWorks Software is configurable for running four stimulators while simultaneously monitoring up to 16 transducers, allowing the researcher maximum flexibility.

The GrowthWorks Control Hardware features an embedded In CPU, integrated data acquisition and integrated motor drives. Communications between the laptop and control hardware is transmitted over a standard network cable. Primary advantages of the BISS Laptop/Controller approach are reduced physical size and easy upgradability. As future Windows versions or higher performance Laptops become available, either can be replaced without any software or controller changes. This ensures the GrowthWorks control system will be an integral part of your research for many years to come.

GrowthApps Stiffness Measurement & Adaptive Control:

The GrowthApps modules provide added capability to GrowthWorks. The addition of the Stiffness Measurement & Adaptive Control Application enables the system to make real-time measurements of the sample stiffness during culture. Described in U.S. Patent 7,410,792 B2 Instrumented bioreactor with material property measurement capability and process-based adjustment for conditioning tissue engineered medical products., the Application measures the mechanical response of the tissue construct as it is being stimulated and conditioned. The stiffness measurements can be used as guidelines for bench marking progress during culturing or for modifying the stimulation profile. Based upon the measured response, the bioreactor system is then capable of altering the stimulation profile. This technology enables researchers to automatically culture the skin from initial seeding to an implantation-ready state with minimal operator intervention.