详细介绍

BioDent活体骨骼质量测试分析仪系统

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BioDent™

What is BioDent™?

BioDent™ is a bench-top Reference Point Indentation platform that enables scientists to easily measure the material properties and function of tissues and biomaterials.

The in vitro to in vivo testing modes set BioDent™ apart from other instruments, enabling the acquisition of data about material properties and function that was previously impossible.

Learn more about BioDent

Why do I need BioDent?
How does BioDent work?
What does BioDent l me?
How easy is BioDent to use?
What can I test with BioDent?

Why do I need BioDent?

Direct Measurements

BioDent allows for direct measurement, rather than a surrogate, of tissue function in a clinically relevant way.

Ease of Use

No extensive technical background is necessary to learn how to use BioDent.

First & Only Solution

BioDent is the first device of its kind. Direct, clinically relevant measurement of tissues is providing never before available insight into tissue function.

It is generally understood that material properties are an important contributor to tissue and biomaterial health. However, no instruments have been available to easily measure these properties in the laboratory in a way that can translate into clinical practice – often causing this important information to be excluded from research. Also, no tools have previously been available to measure tissue material properties in vivo – resulting in frequent exclusion of their evaluation in life science research altogether.

BioDent™ is the first and only solution for life science researchers to easily and directly obtain clinically measurable material properties.

How does BioDent™ work?

BioDent™ uses a microscopic test probe to touch a tissue or biomaterial and evaluate material function/response. The test probe can be sheathed inside a small cannula reference probe which establishes a reference point on or in the sample.

In force-controlled mode, BioDent™ measures the distance the test probe moves relative to the reference point as an indication of how much the material gave-way or flowed when pushed on at controlled force.

For advanced users, a distance-controlled mode BioDent™ measures the force required to push a test probe a predetermined distance into the material, relative to the reference point.

Learn more about how BioDent™ works.

What does BioDent™ l me?

BioDent™ outputs have been used to describe the mechanical effect of tissue health, treatment, and disease. Hard and soft tissues are comprised of many material components that come together to give tissue its desired function. Understanding how tissue function changes due to treatment or disease opens a new perspective on health.

Depending on your setup, BioDent™ can probe across the micrometer to millimeter length scale in order to provide a robust measure across all material components in the tissue or biomaterial. BioDent™ can also provide previously impossible direct, in vivo measures of tissue function – clinically measurable material properties.

How easy is it to use BioDent™?

Like every scientific instrument there is some training required before using BioDent™, however unlike many scientific instruments, no extensive technical background is necessary. Active Life Scientific, Inc. provides all training material with the instrument, sufficient to get a non-technical scientist up and running in a few hours or less. For Advanced Users, certain BioDent™ configurations offer access to waveform control inputs and data analysis outputs through layered interfaces.

In just 30 seconds, a trained user can perform a mechanical test.

Step 1: Attach and position sample.
Step 2: Lower BioDent probe to sample.
Step 3: Click “measure” to gather data in real time.

What tissues and biomaterials can I test with BioDent™?
BioDent™ is designed for in vitro to in vivo testing of a growing number of tissues and biomaterials. Visit Literature to discover the various animals, tissues, and disease/research models already proven on the BioDent™ platform. BioDent™ was initially introduced for hard materials applications, such as bone, however softer materials applications are quickly emerging. Can’t find what you’re interested in testing? Contact Us, we’d love to learn about it.

Translational Research Explore publications highlighting the translational potential of Reference Point Indentation (RPI) technology and how it can be used.	In Vivo Research Explore publications highlighting the in vivo potential of Reference Point Indentation (RPI) technology and how it can be used.	Ex Vivo Explore publications highlighting the versatility of Reference Point Indentation (RPI) technology and how it can be used.

OsteoProbe骨质量测试分析仪系统

活体在体非破坏性地测量两种模式下测试分析活体内骨骼组织的硬度、弹性系数、zui大压痕距离与压痕距离增加值等机械特性（其中压痕距离增加值表示骨折或其他病变组织与正常组织的差异）、测试分析骨内之矿物质含量及分析骨骼微结构，这对于阐明骨科疾病，比如骨质疏松症、关节炎等疾病的发病机制、揭示正常生命机体生长、发育和衰老的机理和自然规律、对于阐明机体骨组织疾病的发病机理及提供诊断和治疗的基本原理均都是具有极其重要的理论和现实意义,以便更好的为临床服务。

OsteoProbe®

Quick. Accurate. Innovative. In Vivo.

The first and only medical device for direct measurement of bone material quality in vivo. Empowering physicians with the ability to measure the material aspects of bone quality for the first time.

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What is OsteoProbe® ?

OsteoProbe® RUO

OsteoProbe® (for research use only in the United States) is a portable handheld microindenter that measures the ability of bone material to resist indentation. Unlike radiological methods (X-ray, DXA and CT) that measure bone mineral density and bone mineral structure, OsteoProbe® measures bone material quaility; an independent component of bone strength.

OsteoProbe® uses Reference Point Indentation (RPI) technology to investigate the bone material’s ability to resist a localized force (resist separation of mineralized collagen fibrils). This is quantified by the Bone Material Strength index (BMSi).