详细介绍

3D软骨压痕仪，3D曲面压痕仪-3D压痕映射和厚度测试分析仪
-多载荷多物理场耦合微观力学性能原位测试系统

biomomentum mach-1

该系统是模块化集成压缩、张力、剪切、摩擦、扭转和2D/3D压痕、3D轮廓及多力混合耦连测试的一体化微观力学测试装置。能对生物组织、聚合物、凝胶、生物材料、胶囊、粘合剂和食品进行精密可靠的机械刺激和表征。允许表征的机械性能包括刚度、强度、模量、粘弹性、塑性、硬度、附着力、肿胀和松弛位移控制运动。

特点

1、适用样品范围广：

1.1、从骨等硬组织材料到脑组织、眼角膜等软组织材料

1.2、从粗椎间盘的样品到极细纤维丝

2、通高量压痕测试分析

◆无需表面平坦，可在不规则表面压痕

◆压痕同时可测量厚度信息

◆压痕不要求压缩轴垂直于样品表面对齐

◆红宝石压头，坚固不易断,使用成本低

◆样品不需要从组织中收集

◆组织的破坏小

◆维持被测材料的机械环境及其与周围材料的相互作用

◆自动mapping

◆亚微米分辨率

◆样品范围广：极软脑组织泡沫到陶瓷、金属

◆力范围广5pa到500Gpa

◆可以在将样品浸入溶液中的情况下进行

2.1、三维法向压痕映射非平面样品整个表面的力学特性

2.2、48孔板中压痕测试分析

3、力学类型测试分析功能齐全

模块化集成压缩、张力、剪切、摩擦、扭转、穿刺、摩擦和2D/3D压痕、3D表面轮廓、3D厚度等各种力学类型支持,微观结构表征及动态力学分析研究

4、高分辨率:

4.1、位移分辨率达0.1um

4.2、力分辨率达0.025mN

5、行程范围广：50-250mm

6、体积小巧、可放入培养箱内

7 、高变分辨率成像跟踪分析

8、多轴向、多力偶联刺激

9、活性组织电位分布测试分析

10、产品成熟，文献量达上千篇

背景介绍：

机械压痕是一种快速、无损的生物组织评价技术。近，Biomomentum对这项技术进行了改进和扩充，它既具有映射绘图能力，又解决了垂直性问题，这仍然妨碍了纳米压痕等其他方法。利用这些突破，新的研究设计的效率大大提高。压痕通常要求被测试的表面是平坦的，并且还需要垂直于关节表面的压缩轴。多轴机械试验机MACH-1 V500 CSS的3D“正常压痕”函数地检测XY位置处的表面高度和方向，并记录载荷（多轴向载荷单元），同时以不同速度移动测试仪的三个阶段，以便以预定义的方式移动球形压头。沿着垂直于样品表面的虚拟轴的位移分布。利用MACH-1 V500 CSS测试器*的多轴能力，生物显微镜已经开发出新的功能，允许压痕测试的所有优点，同时克服了传统的局限性。这一技术进步依赖于在Mach-1运动软件中增加两个功能：“扫描XY”和“正常压痕”。在每个位置执行一系列功能之前，“扫描XY”功能在预定义位置移动测试仪的X和Y水平级。应该提到的是，这样的位置列表可以很容易地生成使用Biomomentum的“软骨映射”软件处理样本的俯视图。“正常缩进”函数地检测出XY位置上的表面的高度和方向，并记录负载（多轴载荷单元），同时以不同的速度移动测试仪的三个阶段，以便沿着一个正常的法线的虚拟轴在样品表面移动球形压头。

纤维丝张力和扭力测

自动法向压痕和厚度映射

胫骨三维轮廓测试

机电活性材料（如结缔组织、带电水凝胶等）压缩过程中电位分布

英文描述：

软骨力学特性其他案例：

3D法向压痕测试典型文献参考

Sensitivity of indentation testing to step-off edges and interface integrity in cartilage repairBae W, Law A, Amiel D and Sah RAnn Biomed Eng, 32(3), 360-369. (2004)

Changes in Free Calcium Alter the Mechanical Properties of the Intervertebral DiscI. Hadjab, M.P. Grant, L.M. Epure, M. Garon, E. Quenneville, J. Anthoniou, F. Mwale and M.D. BuschmannInternational Conference on the Mechanics of Biomaterials and Tissues, Hawaii, USA, 1 2 Dec 2017, Podium O.48. Presented by E. Quenneville

The effect of in vivo chondrocyte depletion on the structural and functional properties of murine articular cartilageA.O. Masson, J.M. Corpuz, W.B. Edwards and R.J. KrawetzOsteoarthritis and Cartilage, April 2019, Volume 27, Supplement 1, Page S80

Quantifying vocal fold wound?healing biomechanical property changesG. R. Dion, T. Guda, S. Mukudai, R.Bing, J-F. Lavoie and R.C. BranskiLaryngoscope. 2019 May 6. doi: 10.1002/lary.27999

Setting up a pre-clinical human model for mechanical induced osteoarthritis to investigate potential pharmacological agentsE. Houtman, M. van Hoolwerff, R. Coutinho De Almeida, A. Rodriguez Ruiz, N. Lakenberg, H.E. Suchiman, M. Tuerlings, R.G. Timmermans, R.G. Nelissen, Y.F. Ramos and I. MeulenbeltOsteoarthritis and Cartilage, April 2019, Volume 27, Supplement 1, Pages S80–S81. doi.org/10.1016/j.joca.2019.02.114

Moderate exercise prevents cartilage softening and muscle structural changes in a rat model of obesityJ.L. Rios, J.W. Mather, J. Michaiel, S.M. Mattiello and W. HerzogOARSI Journal, April 2019 Volume 27, Supplement 1, Page S155

Bottlebrush polymer compositions, lubricating fluid, porous materials comprising said compositions, and surface bearing said compositionsX. Banquy, J. Faivre, B.R.Shrestha, K. Matyjaszewski, J.Burdynska and F. MoldovanUS Patent App. 16/095,051, 2019

A Col1a2 Mutation Reveals Bone Fragility, Hyperelasticity of Skin and Degeneration of Articular Cartilage in MiceS. Sim, A. Blease, M. Garon, E. Quenneville and P. PotterPoster SUN-053. American Society for Bone and Mineral Research, 22 Sep 2019, Orlando, Florida, USA

Biomechanical characterization of tibial articular cartilage in Hyp mice, a murine model of osteoarthritis in X-linked hypophosphatemiaMichael J. Desimone, Steven M. Tommasini, Christopher Cape and Carolyn M. MacicaPoster SUN-929. American Society for Bone and Mineral Research, 22 Sep 2019, Orlando, Florida, USA

Automated Indentation of Femoral and Temporomandibular Joints for Characterization of Cartilage Tissue Quality in Fgf2 KO Mice.Tannin SchmidtPoster SAT-996. American Society for Bone and Mineral Research, 21 Sep 2019, Orlando, Florida, USA

Viscoelasticity and histology of the human cartilage in healthy and degenerated conditions of the kneeMichael Seidenstuecker, Julius Watrinet , Anke Bernstein, Norbert P. Suedkamp , Sergio H. Latorre Anastasija Maks and Hermann O. MayrJournal of Orthopaedic Surgery and Research, November 2019, 14:256. DOI: 10.1186/s13018-019-1308-5

Bioinspired lubrication: from fundamentals to joint protectionX. Banquy, J. Faivre, G. Xie, K. Matyjaszewski, T. Delair, L. David, J. Burdynska, F. Moldovan, S. Benayoun, B. ShresthaICoBT, Montreal, Canada, September 27 2018. Oral presentation S8.1.

Quantifying the Effects of Different Treadmill Training Speeds and Durations on the Health of Rat Knee JointsRios, Jaqueline Lourdes; Boldt, Kevin Rudi; Mather, James William; Seerattan, Ruth Anne; Hart, David Arthur; Herzog, WalterSports Medicine - Open 2018 4:15 doi.org/10.1186/s40798-018-0127-2

Investigating the role of in vivo cell cycle activation within mesenchymal stem cells in the regenerative potential of articular cartilage after injuryMasson, A. O.; Underhill, T. M.; Edwards, W. B.; Krawetz, R. J.Osteoarthritis and Cartilage 26 (2018) S38 doi.org/10.1016/j.joca.2018.02.092

Glycation marker glucosepane increases with the progression of osteoarthritis and correlates with morphological and functional changes of cartilage in vivoLegrand, Catherine; Ahmed, Usman; Anwar, Attia; Rajpoot, Kashif; Pasha, Sabah; Lambert, Cecile; Davidson, Rose K.; Clark, Ian M.; Thornalley, Paul J.; Henrotin, YvesArthritis Research & Therapy 2018 20:131 doi.org/10.1186/s13075-018-1636-6

Contrast-Enhanced Computed Tomography (CECT) attenuation is associated with stiffness of intact knee cartilageNickmanesh, Reza; Stewart, Rachel C.; Snyder, Brian D.; Grinstaff, Mark W.; Masri, Bassam A.; Wilson, David R.J. Orthop. Res. First published: 17 April 2018 doi:10.1002/jor.24022

Automated Indentation Mapping of Vocal Fold Structure and Cover Properties across SpeciesGregory R. Dion, MD, Jean-Francois Lavoie, PhD, Paulo Coelho, DDS, PhD, Milan R. Amin, MD, Ryan C. Branski, PhDLaryngoscope. 2018 Nov 8. doi: 10.1002/lary.27341

Study of the evolution of the osteoarthritis pathology and the mechanical properties of cartilage in a spontaneous osteoarthritis model in the Dunkin-Hartley guinea pigs.Legrand C, Centonze P, Comblain F, Lambert C, Sanchez C and Henrotin YOsteoarthritis and Cartilage, 25, s314-s315.

Electromechanical probe and automated indentation maps are sensitive techniques in assessing early degenerated human articular cartilageSim S, Chevrier A, Garon M, Quenneville E, Lavigne P, Yaroshinsky A, Hoemann CD and Buschmann MDJ Orthop Res, 35(4) 858-867. (2017) Epub 2016 Jun 22

Combined Mechanical Characterizations Increases Sensitivity in the Assessment of Human Cartilage DegenerationSim S, Hadjab I, Chevrolat L-A, Masse M, Tong AL, Lavigne P, Garon M, Quenneville E and Buschmann MDAccepted for a podium presentation at ORS 2017

Indentation and Thickness Mapping of Articular Surfaces through Manual Positioning (Protocol Template AAAX1 v1) Biomomentum Inc. Laval (QC), Canada, Effective Date: December 6th, 2016.

Mach-1 Analysis - Extraction of Elastic Model Parameters Following an Automated Indentation Mapping (SW186-SOP01-D v1)Sim S and Quenneville EBiomomentum Inc. Laval (QC), Canada, Effective Date: April 17th, 2015

Mach-1 – Automated Indentation Mapping (MA056-SOP01-D v2)Sim S and Quenneville EBiomomentum Inc. Laval (QC), Canada, Effective Date: April 7th, 2015

Guidelines for an optimized indentation protocol for measurement of cartilage stiffness - The effects of spatial variation and indentation parametersMoshtagh PR, Pouran B, Korthagen NM, Zadpoor AA and Weinans HJournal of Biomechanics 49(14) · September 2016 DOI: 10.1016/j.jbiomech.2016.09.020

Ermittlung mechanischer Kennwerte mittels IndentationSeidenstucker MBioNanoMat. 2015; 16 (2-3): 152–156 DOI 10.1515/bnm-2015-9014

Evaluation of a novel technique to map the mechanical properties of an entire articular surface in indentationSim S, Quenneville E, Garon M, Hoemann CD, Hurtig M and Buschmann MDInternational Cartilage Repair Society (ICRS), Turkey, 2013, Podium presentation (11.2.9)

Novel Technique to Map the Biomechanical Properties of Entire Articular Surfaces Using Indentation to Identify Osteoarthritis-like RegionsSim S, Chevrier A, Garon M, Quenneville E and Buschmann MDTransactions of the 60th Annual Meeting of the Orthopaedic Research Society, 2014, New Orleans, LA, USA, 2015, Poster #2015

Correlation of Non-destructive Electromechanical Probe (Arthro-BST) Assessment with Histological Scores, Biochemical Composition and Mechanical Properties in Human Knee JointsSim S, Chevrier A, Quenneville E, Garon M and Buschmann MDTransactions of the 60th Annual Meeting of the Orthopaedic Research Society, New Orleans, LA, USA, Poster 0439, 2014

Cartilage Stiffness and Thickness Distributions Revealed by an Automated Indentation Technique in the Temporomandibular JointSim S, Matuska A, Garon M, Quenneville E, McFetridge P and Buschmann MDTMJ Bioengineering Conference - V, September 12-13, 2016, Barcelona, Spain

Development of a Sequence of Mechanical Tests for Articular Cartilage at a Single LocationSim S, Chartrand A, Lavallee AP, Tessier J, Garon M, Quenneville E and Buschmann MDOrthopeadic Research Society Annual Meeting in Orlando, 2016

Wound Healing Revealed by a Novel Automated Indentation TechniqueSim S, Garon M, Quenneville E and Buschmann MDCanadian Connective Tissue Conference 2015 in Quebec, Canada

Evaluation of Entire Ovine Cartilage Repair Articular Surfaces: Mechanical and Electromechanical AssessmentSim S, Hadjab I, Garon M, Quenneville E, Hurtig MB, Buschmann MD and Hoemann CDTransactions of International Cartilage Repair Society (ICRS), Chicago, 2015, 7-11 May 2015, e-Poster: P87

Relevance of the Spatial Distribution of Mechanical Properties of Articular Cartilage in Animal StudiesSim S, Hadjab I, Garon M, Quenneville E, and Buschmann MDOrthopeadic Research Society Annual Meeting in Las Vegas, 2015, Poster 0359

Indentation Method to Map Mechanical Properties of Articular Surface to Identify Degenerated RegionsSim S, Chevrier A, Garon M, Quenneville E and Buschmann MD2014 Annual Meeting of the Biomedical Engineering Society, 2014, San Antonio, TX, USA. Podium presentation (ID: OP-Sat-3-4)

Novel Technique to Map the Biomechanical Properties of Entire Articular Surfaces Using Indentation to Identify Degenerated (Osteoarthritis-like) CartilageSim S, Chevrier A, Garon M, Quenneville E and Buschmann MD7th World Congress on Biomechanics, 2014, Boston, MA, USA. Poster 2229

Novel Technique to Map the Biomechanical Properties of Entire Mice Articular Surfaces Using IndentationSim S, Lavoie JF, Moreau A, Quenneville E, Garon M, and Buschmann MDOsteoarthritis and Cartilage, 22(1), 541. World Congress on Osteoarthritis, April 2014, Paris, France.

Growth Factor Stimulation Improves the Structure and Properties of Scaffold-Free Engineered Auricular Cartilage ConstructsRosa RG, Joazeiro PP, Bianco J, Kunz M, Weber JF, et alPLoS ONE 9(8): e105170. doi:10.1371/journal.pone.0105170. (2014)

Contrast-Enhanced Computed Tomography Reflects Stiffness of Intact Articular CartilageNickmanesh R, Stewart R, Snyder B, Grinstaff M and Wilson DISMRM Workshop on Imaging Based Measures of Osteoarthritis. Sept 11-14, 2015. Pacific Grove, CA, USA. Presentation on Sept 13 at 14:39.

Mapping Articular Cartilage Biomechanical Properties of Normal and Osteoarthritic Mice Using IndentationLavoie JF, Sim S, Quenneville E, Garon M, Moreau A, Buschmann MD and Aubin CEOsteoarthritis and Cartilage 23 Suppl. 2, p. A254 (2015)

Mapping Articular Cartilage Biomechanical Properties of Normal and Osteoarthritic Mice Using Indentation (OARSI Poster)Lavoie JF, Sim S, Quenneville E, Garon M, Moreau A, Buschmann MD and Aubin CEOsteoarthritis Research Society International (OARSI), 2015 April 30, Seattle, WA, United States

Mapping Articular Cartilage Biomechanical Properties of Normal and Osteoarthritis Mice Using IndentationLavoie JF, Sim S, Quenneville E, Garon M, Moreau A, Buschmann MD and Aubin CE2015 International Cartilage Repair Society, May 7-11 2015, Chicago, Illinois, USA. Podium presentation (ID: 23.2.9)

Micro-CT visualization and indentation properties of whole meniscus following mercury exposureKolaczek S, Changoor A, Hurtig M, Gordon K and Getgood AAnnual Meeting of the ORS, New Orleans, Louisiana, USA, March 15-18, 2014.

Assessment of Human Articular Cartilage Issued from Asymptomatic & TKR DonorsHadjab I, Sim S, Quenneville E, Garon M and Buschmann MDBiomedical Engineering Society 2015 in Tampa, Floride

Development and Validation of Large-Sized Engineering Cartilage Constructs in Full-Thickness Chondral Defects in a Rabbit ModelBrenner JMaster thesis Queen's University. (2012)

Indentation probing of human articular cartilage: effect on chondrocyte viabilityBae W, Schumacher B and Sah ROsteoarthritis and Cartilage, 15(1), 9-18. (2007)

硬度微压痕测试文献

Mach-1 - Hardness Testing (MA056-SOP12-D v1)Gilbert N and Quenneville EBiomomentum Inc. Laval (QC), Canada, Effective Date: December 9th, 2016

Purpose: This procedure describes a standard method to realize an indentation hardness test on a material sample using the Mach-1 mechanical tester.

Scope: This procedure can be applied on any type of material with shape and dimension compatible with the specifications presented in the material section while the expected hardness results remain within tester..

ASTM E384 - Standard Test Method for Microindentation Hardness of Materials ASTM International, West Conshohocken, PA, 2016,

Significance and Use

5.1 Hardness tests have been found to be very useful for materials evaluation, quality control of manufacturing processes and research and development efforts. Hardness, although empirical in nature, can be correlated to tensile strength for many metals and alloys, and is also an indicator of machinability, wear resistance, toughness and ductility.

ASTM C1327 - Standard Test Method for Vickers Indentation Hardness of Advanced Ceramics ASTM International, West Conshohocken, PA, 2015,

刚度压痕测试文献

Sensitivity of indentation testing to step-off edges and interface integrity in cartilage repairBae W, Law A, Amiel D and Sah RAnn Biomed Eng, 32(3), 360-369. (2004)

Indentation probing of human articular cartilage: effect on chondrocyte viabilityBae W, Schumacher B and Sah ROsteoarthritis and Cartilage, 15(1), 9-18. (2007)

Novel Biomechanical Indentation Test Demonstrates Joint Surface Weakening in Mice Lacking Fibroblast Growth Factor Receptor 3 (FGFR3)Binette JS, Laflamme F, Li W, Valverde-Franco G, Tran-Khanh N, Quenneville E, Henderson JE and Buschmann MDPaper presented at the 11th Canadian Connective Tissue Conference, Montreal, QC, Canada. (2005)

Development and Validation of Large-Sized Engineering Cartilage Constructs in Full-Thickness Chondral Defects in a Rabbit ModelBrenner JMaster thesis Queen's University. (2012)

Association of 3-dimensional cartilage and bone structure with articular cartilage properties in and adjacent to autologous osteochondral grafts after 6 and 12 months in a goat modelChan EF, Liu IL, Semler EJ, Aberman HM, Simon TM, Chen AC, Truncale KG and Sah RLCartilage, 3(3), 255-266. (2012)

Development of scaffold-free elastic cartilaginous constructs with structural similarities to auricular cartilageGiardini-Rosa R, Joazeiro PP, Thomas K, Collavino K, Weber J and Waldman SDTissue Engineering Part A. Volume 20, Numbers 5 and 6, 2014, pp 1012-26 (2014)

Engineering of Hyaline Cartilage with a Calcified Zone Using Bone Marrow Stromal CellsLee WD, Hurtig MB, Pilliar RM, Stanford WL and Kandel RAOsteoarthritis and Cartilage (2015), doi: 10.1016/j.joca.2015.04.010

Soft Tissue Phantoms for Realistic Needle Insertion - A Comparative StudyLeibinger A, Forte AE, Tan Z, Oldfield MJ, Beyrau F, Dini D and Rodriguez y Baena FAnnals of Biomedical Engineering. pp 1-11 (2015)

Characterization of the effect of microfracture surgery and angle of incidence on the structural properties of femoral boneLiang LD, Wagner A, Steeds J, Hurtig M and Gordon KStudies by Undergraduate Researchers at Guelph, 7(1), 56-61. (2013)

Low Magnitude High Frequency Vibration Accelerated Cartilage Degeneration but Improved Epiphyseal Bone Formation in Anterior Cruciate Ligament Transect Induced Osteoarthritis Rat ModelQin J, Chow S KH, Guo A, Wong WN., Leung KS and Cheung WHOsteoarthritis and Cartilage. July 2014, Vol.22(7):1061–1067. (2014)

Wound Healing Revealed by a Novel Automated Indentation TechniqueSim S, Garon M, Quenneville E and Buschmann MDCanadian Connective Tissue Conference 2015 in Quebec, Canada

Elastic modulus of 316 stainless steel lattice structure fabricated via binder jetting processTang Y, Zhou Y, Hoff T, Garon M and Zhao FYMaterials Science and Technology 32(7):1743284715Y.000 · June 2015 DOI: 10.1179/1743284715Y.0000000084

Defective Bone Mineralization and Osteopenia in Young Adult Fgfr3-/- MiceValverde-Franco G, Liu H, Davidson D, Chai S, Valderrama-Carvajal H, Goltzman D, Ornitz DM and Henderson JEHum Mol Genet, 13(3), 271-284

Defects in articular cartilage metabolism and early arthritis in fibroblast growth factor receptor 3 deficient miceValverde-Franco G, Binette JS, Li W, Wang H, Chai S, Laflamme F, Tran-Khanh N, Quenneville E, Meijers T, Poole AR, Mort JS, Buschmann MD and Henderson JEHuman molecular genetics, 15(11), 1783-1792. (2006)

The Effects of Oxidative Stress on the Compressive Damage Thresholds of C2C12 Mouse Myoblasts: Implications for Deep Tissue InjuryYao Y, Xiao Z, Wong S, Hsu YC, Cheng T, Chang CC, Bian L and Mak AFAnn Biomed Eng. 2015 Feb;43(2):287-96. doi: 10.1007/s10439-014-1239-6. Epub 2015 Jan 6.

A composite hydrogel for brain tissue phantomsForte AE, Galvan S, Manieri F,y Baena FR and Dini DMaterials & Design, 112, 227-238 (2016)

Biomechanical Characterisation of the Human Auricular Cartilage - Implications for Tissue EngineeringGriffin MF, Premakumar Y, Seifalian M, Szarko and Butler PEMAnnals of Biomedical Engineering, 2016. Punlished online, 14Jul2016. DOI: 10.1007/s10439-016-1688-1

Streaming Potential-Based Arthroscopic Device Discerns Topographical Differences In Cartilage Covered And Uncovered By Meniscus In Ovine Stifle JointsChangoor A, Quenneville E, Garon M, Cloutier L, Hurtig MB and Buschmann MDTransactions of the 53th Annual Meeting of the Orthopaedic Research Society, San Diego, CA, USA, 32:631. (2007)

ASTM F2451-05 - Standard Guide for in vivo Assessment of Implantable Devices Intended to Repair or Regenerate Articular Cartilage ASTM International, West Conshohocken, PA, 2010,

Change in viability of C2C12 myoblasts under compression, shear and oxidative challengesHong Y, Yao Y, Wong S, Bian L and Mak AFJournal of biomechanics, 49(8), 1305-1310. (2016)

The Verification of the Mechanical Properties of Binder Jetting Manufactured Parts by Instrumented Indentation TestingZhou Y, Tang Y, Hoff T, Garon M and Fiona Yaoyao Zhao43rd Proceedingsof the North American Manufacturing Research. Volume 1, Pages 327–342. (2014)

Review Paper: Fifty years of brain tissue mechanical testing: From in vitro to in vivo investigationsChatelin S, Constantinesco A and Willinger RBiorheology 47 (2010) 255–276. DOI 10.3233/BIR-2010-0576

Indentation and Thickness Mapping of Articular Surfaces through Manual Positioning (Protocol Template AAAX1 v1) Biomomentum Inc. Laval (QC), Canada, Effective Date: December 6th, 2016.

Comparisons of Auricular Cartilage Tissues from Different SpeciesLLY Chiu, R Giardini-Rosa, JF Weber, SL Cushing and SD WaldmanAnn Otol Rhinol Laryngol. 2017 Dec;126(12):819-828. doi: 10.1177/0003489417738789. Epub 2017 Oct 27.

In Situ Cross-Linking of Poly (vinyl alcohol)/Graphene Oxide–Polyethylene Glycol Nanocomposite Hydrogels as Artificial Cartilage Replacement: Intercalation Structure, Unconfined Compressive Behavior, and Biotribological BehaviorsMeng, Yeqiao; Ye, Lin; Coates, Phil; Twigg, PeterJ. Phys. Chem. C, 2018, 122 (5), pp 3157–3167 DOI: 10.1021/acs.jpcc.7b12465

Optimising the decellularization of human elastic cartilage with trypsin for future use in ear reconstructionRahman, Shafiq; Griffin, Michelle; Naik, Anish; Szarko, Matthew; Butler, Peter EMScientific Reports (2018) 8:3097 DOI:10.1038/s41598-018-20592-x

Long Term Efficacy of Cartilage Repair Induced By scSOX9 in Situ with Bone Marrow-Derived Mesenchymal Stem CellsZhang X, Wu S, Zhu Y, Chu CQArthritis Rheumatol. 2018; 70 (suppl 10). Abstract Number 850

Dynamic covalent Schiff-base silicone polymers and elastomersRobert Bui and Michael A. BrookPolymer. Volume 160, 3 January 2019, Pages 282-290 doi.org/10.1016/j.polymer.2018.11.043

Multi-modal characterization of polymeric gels to determine the influence of testing method on observed elastic modulusDavid M. Kingsley, Caitlin H.McCleery, Christopher D.L.Johnson, Michael T.K.Bramson, Deniz Rende, Ryan J.Gilbert, David T.CorrJournal of the Mechanical Behavior of Biomedical Materials, available online 10 January 2019, doi.org/10.1016/j.jmbbm.2019.01.003

A study of saliva lubrication using a compliant oral mimicG. Carpenter, S. Bozorgi, S. Vladescu, A.E. Forte, C. Myant, R.V. Potineni, T. Reddyhoff, and S.K. BaierFood Hydrocolloids, Elsevier, Available online 23 January 2019, doi.org/10.1016/j.foodhyd.2019.01.049

Intervertebral disc implantR Kandel, JP Santerre, SQ LiUS Patent App. 10195044, 2019

Ultrashort Time to Echo Magnetic Resonance Evaluation of Calcium Pyrophosphate Crystal Deposition in Human MenisciFinkenstaedt T, Biswas R, Abeydeera NA, Siriwanarangsun P, Healey R, Statum S, Bae WC and Chung CBInvest Radiol. 2019 Jun. 54(6):349-355.

Simulation of Acoustic Propagation in 3D Viscoelastic Inhomogeneous Media with Application to Medical Shear Wave ElastographyP. S. Bidari, H. Assi, R. S. C. Cobbold, J. Alirezaie and J. TavakkoliJournal of Theoretical and Computational Acoustics Vol. 27, No. 03, 1950003 (2019) Research Papers, doi.org/10.1142/S2591728519500038

3D压痕厚度测试文献

Sensitivity of indentation testing to step-off edges and interface integrity in cartilage repairBae W, Law A, Amiel D and Sah RAnn Biomed Eng, 32(3), 360-369. (2004)

Development and Validation of Large-Sized Engineering Cartilage Constructs in Full-Thickness Chondral Defects in a Rabbit ModelBrenner JMaster thesis Queen's University. (2012)

Assessment of Human Articular Cartilage Issued from Asymptomatic & TKR DonorsHadjab I, Sim S, Quenneville E, Garon M and Buschmann MDBiomedical Engineering Society 2015 in Tampa, Floride

Wound Healing Revealed by a Novel Automated Indentation TechniqueSim S, Garon M, Quenneville E and Buschmann MDCanadian Connective Tissue Conference 2015 in Quebec, Canada

Mach - Automated Thickness Mapping of an Articular Surface (MA056-SOP02-D v2)Sim S and Quenneville EBiomomentum Inc. Laval (QC), Canada, Effective Date: April 7th, 2015

Mach-1 Analysis - Extraction of Thickness Values Following Automated Thickness Mapping of an Articular Surface (SW186-SOP02-D v1)Sim S, Lavoie JF and Quenneville EBiomomentum Inc. Laval (QC), Canada, Effective Date: April 22th, 2015

The effect of in vivo chondrocyte dsepletion on the structural and functional properties of murine articular cartilageA.O. Masson, J.M. Corpuz, W.B. Edwards and R.J. KrawetzOsteoarthritis and Cartilage, April 2019, Volume 27, Supplement 1, Page S80

产品简介

详细介绍

3D软骨压痕仪，3D曲面压痕仪-3D压痕映射和厚度测试分析仪
-多载荷多物理场耦合微观力学性能原位测试系统

biomomentum mach-1

英文描述：

软骨力学特性其他案例：

3D法向压痕测试典型文献参考

常用功能直达

产品简介

详细介绍

3D软骨压痕仪，3D曲面压痕仪-3D压痕映射和厚度测试分析仪 -多载荷多物理场耦合微观力学性能原位测试系统

biomomentum mach-1

英文描述：

软骨力学特性其他案例：

3D法向压痕测试典型文献参考

常用功能直达

3D软骨压痕仪，3D曲面压痕仪-3D压痕映射和厚度测试分析仪
-多载荷多物理场耦合微观力学性能原位测试系统