StemRD GDC-0449, SMO antagonist 拮抗剂

GDC-25StemRD GDC-0449, SMO antagonist 拮抗剂

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2016-12-28 09:44:39
2009
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重庆市华雅干细胞技术有限公司

重庆市华雅干细胞技术有限公司

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StemRD GDC-0449, SMO antagonist 拮抗剂
规格型号:25mg/支

详细介绍

StemRD GDC-0449, SMO antagonist 拮抗剂 产品英文简述:

GDC-0449 (Vismodegib): A potent antagonist of SMO (smoothened). This small molecule compound is a hedgehog pathway inhibitor by directly binding to SMO. This molecule has been developed by Genentech for clinical application against hedgehog-dependent cancers.
 
Purity: Greater than 99% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request.
Biological Activity: In a cell-based assay measuring the activation of the Gli-1 reporter gene, this compound gives IC50 of 5-20 nM.

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