CBP71363-CCR8/β-Arrestin/CHO GPCR细胞_GPCR细胞株-南京科佰生物科技有限公司手机版

详细介绍

CBP71363
I. Background
C-C chemokine receptor type 1 (CCR8) is a G protein-coupled receptor member of the CC chemokine subfamily of receptors. Following interaction with its specific chemokine ligands, like macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), and monocyte chemoattractant protein 3 (MCP-3), it triggers the onset of a process known as chemotaxis. GenScript’s human CCR8-expressing stable subline is guaranteed to function properly in the calcium flux assay.

II. Introduction
Host Cell:	CHO
Stability:	20 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Freeze Medium:	90% FBS+10% DMSO
Culture Medium:	N/A
Mycoplasma Status:	Negative
Storage:	Liquid nitrogen immediately upon delivery
Application(s):	Functional assay for CCR8 receptor
Transducer:	Gi

Ⅲ. Description of Host Cell Line
Organism:	Hamster
Tissue:	Ovary
Morphology:	Epithelial
Growth Properties:	Adherent

Ⅳ. Representative Data
Figure 1. Dose response of Human Recombinant CCL1 in CCR8 β-Arrestin/CHO-K1 Cell Line (C6).
Figure 2. Inhibition of CCL1-induced Beta-Arrestin Recruitment By CCR8 Blocking Ab in CCR8 Beta-Arrestin CHO-K1 Cells.