cobioer/科佰生物 品牌
代理商厂商性质
南京市所在地
| CBP73380 | |
| I. Introduction | |
| Cell Line Name： | KRAS G12C-A59T/BaF3 |
| Host Cell: | Ba/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Application: | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
| Freeze Medium: | 90% FBS+10% DMSO |
| Complete Culture Medium: | RPMI-1640+10%FBS+2ug/ml puromycin |
| Mycoplasma Status: | Negative |
| II.Background | |
KRAS, KRAS proto-oncogene, GTPase, is a member of the small GTPase superfamily and a key regulator of the MAPK, PI3K/AKT/mTOR pathways (PMID: 23622131). KRAS mutations are identified in a wide range of cancers (PMID: 28666118). | |
| III. Representative Data | |
1. Sanger of KRAS G12C-A59T/BaF3
Figure 1. KRAS G12C-A59T/BaF3 G12C
Figure 2. KRAS G12C-A59T/BaF3 A59T | |
2. Anti-proliferation assay
Figure 3. CTG Proliferation Assay of KRAS G12C/A59T BaF3 Cells (C13). | |
![CBP73380 sanger-G12C [G12C]Baf3 KRAS G12C+A59T-C13.jpg](https://img66.chem17.com/dad3ae7f7c25ee0134c6d0bcb4909aabe92f92fc32069b8bb7f118a5e6e6a0a2ce4908d3828bd6ea.jpg "CBP73380 sanger-G12C [G12C]Baf3 KRAS G12C+A59T-C13.jpg")
![CBP73380 sanger-A59T [A59T]Baf3 KRAS G12C+A59T-C13.jpg](https://img65.chem17.com/dad3ae7f7c25ee0134c6d0bcb4909aab2e742fb15ab2dd1e3f5d58ee16cc321684e1bc228363230c.jpg "CBP73380 sanger-A59T [A59T]Baf3 KRAS G12C+A59T-C13.jpg")
