60513-ARE Luciferase Reporter HepG2 Cell Line (Nrf2 Antioxidant Pathway)_Cell Signaling Pathway Cell Lines-BPS Bioscience Inc.手机版

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Description

The antioxidant response element (ARE) Luciferase Reporter HepG2 hepatic cell line contains a stably integrated firefly luciferase reporter under the control of ARE, which is recognized by the transcription factor Nuclear factor erythroid 2-related factor 2 (Nrf2). Luciferase expression correlates with activation of Nrf2 and the antioxidant pathway. This cell line was validated by stimulation with tert-butylhydroquinone, sulforaphane, and RTA-408 (omaveloxone).

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Figure 1: Illustration of the ARE Luciferase Reporter HepG2 Cell Line (Nrf2 Antioxidant Pathway) mechanism.

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Purchase of this cell line is for research purposes only; commercial use requires a separate license. View the full terms and conditions.

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Synonyms

ARE cell line, Nrf2 reporter, Nrf, Hepg2, ARE

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Product Data Gallery

ARE Luciferase Reporter HepG2 cells response to sulforaphane (3 µM) and tert-butylhydroquinone (160 µM).

Dose response of sulforaphane in ARE Luciferase Reporter HepG2 cells. The results are shown as fold induction of unstimulated luciferase activity.

Dose response of ARE Luciferase Reporter HepG2 cells to RTA-408.

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