BPS Bioscience 品牌
生产厂家厂商性质
所在地
ATAT1, GST-tag Recombinant
面议
ATF2, GST-Tag Recombinant
面议
GCN5 (727-837), His-tag Recombinant
面议
GCN5 (KAT2A), FLAG-tag Recombinant
面议
p300 (KAT3B), His-GST-tag Recombinant
面议
ACHE, His-Tag Recombinant
面议
APAF1, His-tag, FLAG-tag Recombinant
面议
BCL-2, His-Tag Recombinant
面议
BCL2A1, His-Tag Recombinant
面议
BCL2L10, His-Tag Recombinant
面议
Caspase6, His-tag Recombinant
面议
Caspase7, His-tag Recombinant
面议The Anti-mesothelin CAR-T cells are produced by high-titer lentiviral transduction of human primary CD4+CD8+ T cells using the anti-Mesothelin CAR Lentivirus (Mesothelin ScFv-CD8-4-1BB-CD3ζ; BPS Bioscience #78703). These ready-to use CAR-T cells express an anti-Mesothelin CAR consisting of the scFv (Single chain fragment variable) of anti-Mesothelin (clone P4) linked to a 2nd generation CAR (Chimeric Antigen Receptor) containing CD8 hinge and transmembrane domains, and the 4-1BB and CD3ζ signaling domains (Figure 1).
These CAR-T cells have been validated using flow cytometry (to determine the CAR expression) and co-culture cytotoxicity assays.
Figure 1: Construct diagram showing components of the anti-Mesothelin CAR expressed in anti-Mesothelin CAR-T cells.
