The GCN5 Chemiluminescent Assay Kit is an enzyme-linked immunosorbent assay (ELISA) designed to screen for inhibitors of GCN5 or to measure histone acetyltransferase (HAT) activity for screening and profiling applications. Histone acetyltransferase GCN5 (also known as KAT2A) is involved in various cellular events, and its dysfunction is linked to a number of human diseases including cancers and diabetes. The GCN5 Chemiluminescent Assay Kit is based on the GCN5 enzyme transferring an acetyl group from an acetyl donor (acetyl CoA) to a histone substrate. The acetylated histone is recognized by a highly specific primary antibody, followed by an HRP-labeled secondary antibody. The chemiluminescence produced by HRP can be measured using a chemiluminescence reader.

This product has been cited 2 times.