Anti-AQP3，水通道蛋白-3抗体-化工仪器网-手机版

Anti-AQP3

产品类别产品目录>> 一抗>> 一抗

产品编号by-1253R

英文名称Anti-AQP3
中文名称水通道蛋白-3抗体

别名
AQP 3; AQP3; Aquaporin 3 （GIL blood group）; Aquaporin 3 （Gill blood group）; Aquaporin3; GIL;
Gill blood group.

产品价格0.1ml/100μg/780元0.2ml/200μg/1100元

浓度1mg/1ml
抗体来源Rabbit
克隆类型polyclonal
交叉反应hu, rat, mo
产品类型一抗

研究领域肿瘤信号转导通道蛋白
蛋白分子量predicted molecular weight: 32kDa
性状Lyophilized or Liquid
免疫原KLH conjugated synthetic peptide derived from human AQP3 C-terminus
亚型IgG

纯化方法

affinity purified by Protein A
储存液0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

产品应用

WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500
IF=1:100-500（石蜡切片需做抗原修复）notyettestedinotherapplications.optimaldilutions/concentrations should be determined by the end user.

保存条件

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody
is stable at room temperature for at least one month and for greater than a year when kept
at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody
is stable for at least two weeks at 2-4 °C.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic
or diagnostic applications.

产品介绍

Water is a critical component of all living cells. Interestingly, tissue membranes show a
Anti-AQP3
great degree of water permeability. Mammalian red cells, renal proximal tubules, and
descending thin limb of Henle are extraordinarily permeable to water. Water crosses
hydrophobic plasma membranes either by simple diffusion or through a facilitative transport
mechanism mediated by special protein "aquaporin". Over the last decade, genes for several
members of aquaporin family have been cloned, expressed, and their distribution studied in
many tissues. AQP0 or MIP26 （major intrinsic protein 26kD）, and Aquaporin-1 （AQP1, purified
from red cells） also called CHIP-28 （channel forming integral protein, 28kD; 268aa; gene locus
7p14） has been the foundation of the growing family of aquaporin. The lens specific AQP0
represents up to 80% of total lens membrane protein. Defects in MIP26 are cause of autosomal
dominant cataract. The cataract Fraser mutation （CAT-FR or Shriveled） is a transposon-induced
splicing error that substitutes a long terminal repeat sequence for the c-terminus of MIP.
The lens opacity mutation （LOP） is an amino acid substitution that inhibits targeting of MIP
to the cell membrane.
AQP3 （GLIP, Glycerol-transporting integral protein; 28a; 31.4kD） has a wide tissue
distribution. AQP3 may function as a water and urea exit mechanism in antidiuresis in
collecting duct cells. It is also slightly permeable to urea and glycerol. AQP3 may play an
important role in gastrointestinal tract water transport and in glycerol metabolism. In the
kidney it is predominantly expressed in the inner medulla. AQP families of proteins are
predicted to contain six transmembrane domains. The N and C-terminus are predicted to be
cytoplasmic.
Subcellular Location : Membrane; Multi-pass membrane protein.
Tissue Specificity : Renal medulla and colon. Predominantly in the inner medulla. Expressed in basal
Anti-AQP3
layer of epidermal keratinocytes.
Similarity : Belongs to the MIP/aquaporin （TC 1.A.8） family.

通道蛋白（Channel Protein）
AQP 3主要分布于肾脏集合管上皮细胞基侧质膜,除了对水有通透性外、还可转运尿素和甘油等小分子
物质,而尿素在尿液浓缩机制中有着重要的作用.
有学者认为：AQP-3的阳性率与某些肿瘤分化程度有关（胃癌、结肠癌、乳腺癌、前列腺癌、子宫癌、
卵巢癌、甲状腺癌等）

技术文章

Anti-AQP3，水通道蛋白-3抗体

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